急性脑梗死患者镁代谢的变化及临床意义  

Magnesium Metabolism Change and Therapy in Acute Cerebral Infarction

作　　者：黄志红[1] 黄志[1] 肖立中[1] 胡碧花 

机构地区：[1]广东省韶关市粤北人民医院老年病科,广东韶关512026

出　　处：《中国现代医生》2010年第24期31-32,共2页China Modern Doctor

摘　　要：目的观察急性脑梗死患者镁代谢的变化及卡维地洛对其影响。方法 60例急性脑梗死患者随机分为两组,谷维素组和卡维地洛组,两组治疗前后分别测定血浆镁浓度(PMC)、外周血单核细胞镁含量(MMC)及24h尿镁排泄量(UME),并选择28例健康者为正常对照组。结果与正常对照比较,急性脑梗死患者UME明显升高(P<0.01),PMC、MMC降低(P<0.01),且三者与脑梗死面积、神经缺损评分相关(P<0.01),经卡维地洛治疗后各指标均明显改善。结论急性脑梗死患者镁代谢紊乱与脑梗死面积、神经缺损评分密切相关,卡维地洛能明显改善镁代谢及神经缺损评分。Objective To investigate the magnesium metabolism change and the effect of carvedilol on magnesium metabolism in acute cerebral infarction （ACI）. Methods Sixty cases of ACI were included. The excretion of urine magnesium （UME）,plasma level of magnesium （PMC）, and intramonocyte magnesium content （MMC） were measured before and after treatment, and 28 health persons were selected as normal control. Results UME was increased, PMC and MMC were decreased in ACI,compared with the control group （P〈0.01）,and UME, PMC and MMC were correlated with the cerebral infarction area and the neurologic impairment score （P〈0.01）. All these parameters were significantly improved after treatment with carvedilol. Conclusion Carvedilol improves the magnesium metabolism and the neurologic impairment score in ACI.

关 键 词：脑梗死 镁 镁代谢 卡维地洛 

分 类 号：R743.3[医药卫生—神经病学与精神病学]