5-氨基酮戊酸光动力疗法对头面部皮肤肿瘤美容治疗的疗效  

Cosmetic efficacy of topical 5-aminolaevulinic acid-photodynamic therapy on cephalic and facial skin tumors

作　　者：李强[1] 胡雪慧[1] 焦彬[2] 齐显龙[1] 罗莉[1] 高天文[1] 

机构地区：[1]第四军医大学西京医院皮肤科,西安710032 [2]武警北京总队医院皮肤科

出　　处：《中华医学美学美容杂志》2010年第4期217-219,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的 总结及分析5-氨基酮戊酸光动力疗法（ALA-PDT）治疗头面部皮肤肿瘤的临床疗效及外观结果.方法 选择头面部皮肤肿瘤患者,包括基底细胞癌（BCC）、鳞状细胞癌（SCC）、脂溢性角化病（KS）及日光性角化病（SK）,均病理诊断确诊且不愿意接受手术,进行ALA-PDT治疗,随访3个月,对临床疗效进行评价.结果 28例头面部皮肤肿瘤患者,BCC 16例、SCC 8例、KS 2例、SK 2例.BCC有效率100%,痊愈15例,复发1例;SCC有效率67%,其中2例未坚持治疗,3例痊愈,1例显效,1例好转,1例无效;KS有效率为0;SK 2例,痊愈1例,显效1例,有效率100%.美容效果评价中64.2%（18例）患者认为非常满意;11%（3例）满意;7.1%（2例）一般;10.7%（3例）差.结论 ALA-PDT对于不愿意接受手术治疗的头面部皮肤BCC、SCC及SK患者临床疗效及美容效果评价满意,对于KS无效.Objective To investigate and summarize the clinieal effects and cosmetic results of 5-aminolaevulinic acid-photodynamic therapy （ALA-PDT） on cephalic and facial skin tumors.Methods Patientswith skin basal eell carcinoma（BCC）,squamous cell carcinoma （SCC）,keratosis seborrheica （KS）,and solar keratosis （SK） were included in this study.Inoperable cases were given topical ALAPDT,and received clinical response evaluation and satisfying questionnaire after 3 months follow-up.Resalts28 patients including 16 BCCs,8 SCCs,2 KSs and 2 SKs received ALA-PDT.100% BCC had responseto PDT,including 15 cases with complete response （CR）;only one recurred.Overall response rate was 67% for SCC,2 of 8 cases failed to continue the treatment,3 eases CR,1 case partial response （PR） and 1 patient with no response.Response rate was 0% in KS.100% of SK had response to PDT,and 2 cases showed CR and PR,respectively.64.2% patients （18/28） showed extreme satisfaction for cosmetic outcome,11% （3 cases） satisfaction,7.1% （2 cases） little satisfaction,and 10.7% （3 cases） no satisfaction.Conclusion Topical ALA-PDT is an effective and satisfied treatment with lower recurrent rates, especially for cephalic and facial skin tumors including BCC,SCC and SK,but no response for KS.

关 键 词：光动力治疗 5-氨基酮戊酸 皮肤肿瘤 面部 

分 类 号：R739.5[医药卫生—肿瘤]