5-羟色胺2A受体基因多态性与帕罗西汀临床疗效的关联研究  

Study on the relationship between serotonin receptor 2A gene polymorphism and clinical response to paroxetine

作　　者：武聪丽[1] 岳伟华[1] 宓为峰[1] 张瑞[1] 杜波[2] 谭云龙[3] 张瑞国[4] 马现仓[5] 张鸿燕[1] 

机构地区：[1]北京大学精神卫生研究所,卫生部精神卫生学重点实验室,北京100191 [2]河北省精神卫生中心,河北保定071000 [3]北京回龙观医院,北京100096 [4]第四军医大学西京医院心身科,西安710032 [5]西安交通大学第一医院精神科,西安710061

出　　处：《中国临床药理学杂志》2010年第8期577-580,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的研究中国汉族重性抑郁症(MDD)患者5-羟色胺2A受体基因多态性与帕罗西汀抗抑郁临床疗效之间的关系。方法 117例抑郁症患者给予帕罗西汀(20～50mg.d-1)治疗8周,用汉密尔顿抑郁量表(HAMD-17)评估临床疗效,聚合酶链式反应(PCR)和限制酶切的方法检测A1438G基因型。结果有效率、缓解率及不良反应发生率在A1438G不同基因型及等位基因间分布差异无统计学意义(P>0.05);G等位基因携带者睡眠症状改善好。结论 A1438G多态性与帕罗西汀对睡眠症状的改善有关。Objective To investigate the relationship between serotonin receptor 2A（5 -HT2A） gene polymorphism and clinical response to paroxetine in Chinese major depressive disorder （MDD） patients. Methods One hundred senventeen patients affected by MDD were treated with paroxetine for 8 weeks. The clinical response was evaluated with the Hamilton Rating Scale for Depression （ HAMD - 17 ） , and adverse drug reactions were assessed at each visit. PCR - RFLP was used to detect A1438G gene polymorphism. The relations between genetypes and clinical response ,adverse drug reactions were analysed. Results There was significant differences of main clinical response and adverse drug reactions （ADRs） among different genotypes and allele carriers. There were significant differences between G carriers and G non - carriers in sleep symptom improvement. Conclusion The 5 - HT2A reeeptor gene polymophism A1438G was associated with the sleep symptom improvement of MDD.

关 键 词：重性抑郁障碍 帕罗西汀 5-羟色胺2A受体 受体基因多态性 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R971.43[医药卫生—临床医学]