重组人酸性成纤维细胞生长因子治疗重型口腔溃疡的临床疗效观察  

Curative effects of recombinant human acidic fibroblast growth factor on major oral ulcer

作　　者：张英[1] 闻妍[1] 康媛媛[1] 

机构地区：[1]中国医科大学口腔医学院综合急诊科,沈阳110002

出　　处：《中国临床药理学杂志》2010年第8期627-629,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价酸性成纤维细胞生长因子(促溃疡愈合药)治疗重型口腔溃疡临床疗效。方法收集口腔深溃疡患者97例,其中包括重型复发性阿弗他溃疡(MaRAU)患者63例,随机分为3组,分别用封闭治疗、局部用药、封闭及局部用药联合的治疗方法;另有创伤性溃疡34例,随机分为2组:对照不经药物治疗,治疗组局部用药治疗。结果察患者疼痛时间,其中MaRAU患者中,封闭疗法组与局部用药组有显著性差异;封闭疗法组与结合疗法组无显著性差异;局部用药组与结合疗法组有显著性差异。创伤性溃疡患者中,对照组与用药组无显著性差异。溃疡愈合后,评价平均溃疡期以及是否留有瘢痕:MaRAU及创伤性溃疡患者中,各组间均有显著性差异。结论单用药外用可以促进溃疡愈合,但疼痛缓解作用较弱。局部封闭与用药结合疗法对重型溃疡疗效显著。Objective To evaluate the effects of recombinant human acidic fibroblast growth factor （rhaFGF）on patients with major oral ulcer. Methods Ninety seven cases were chosen including sixty three MaRAU patients and randomly divided into three groups. They were treated with injection, rhaFGF external application and combination therapy. Thirty four traumatic ulceration patients were randomly divided into two groups. Control group was given no medicine and treatment group were treated with rhaFGF external application. Results Observing the time pain for MaRAU patients, there were significant difference between injection group and rhaFGF external applications group, rhaFGF external application group and combination therapy group, and no significant difference between injection group and combination therapy group. For traumatic ulceration patients, there was no significant difference between control group and treatment group. After ulcer healing, we evaluated the average ulcer period and whether scar and found significant difference between patients in each group. Conclusion Using rhaFGF alone can promote healing, but the role of pain relief are weak. The rhaFGF combined with injection has a good clinical effect on major oral ulcer.

关 键 词：重组人酸性成纤维细胞生长因子 重型溃疡 局部封闭 

分 类 号：R781.51[医药卫生—口腔医学] R988.2[医药卫生—临床医学]