网络成瘾患者冲动控制功能的事件相关电位研究  

An event-related potential investigation of deficient inhibitory control in individuals with internet addiction disorder

作　　者：周振和[1] 袁国桢[1] 姚建军[1] 李翠[1] 程灶火[1] 

机构地区：[1]南京医科大学附属无锡精神卫生中心临床心理科,南京214151

出　　处：《中华行为医学与脑科学杂志》2010年第8期701-703,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：江苏省自然基金资助项目（BK2007024）

摘　　要：目的 通过对网络成瘾（IAD）个体执行视觉反应/不反应（Go/No-go）任务的事件相关电位特征检测,探讨IAD冲动控制功能缺陷的发生机制.方法 符合修订的Young网络成瘾诊断问卷（YDQ）IAD标准的26例患者作为研究组,与研究组匹配性别、年龄的26例健康人作为对照组.Go/No-go任务刺激由8个不同的双数字组成.刺激反应时间1000ms,刺激间隔1500ms.记录被试者执行任务时的脑电图.Barratt-11冲动性量表（BIS-11）评估被试者冲动性.应用BESA 5.2.0软件离线分析No-go刺激的N2波幅.结果 IAD组BIS-11总分、注意因子分、运动因子分[分别为（77.32±7.53）分,（32.04±2.34）分,（23.31±2.94）分]明显高于对照组[分别为（72.79±5.73）分,（30.27±1.85）分,（22.05±2.20）分]（P＜0.05）,2组计划因子分差异无统计学意义（P＞0.05）;IAD组错误率（0.042±0.007）明显高于对照组（0.015±0.006）,而正确率（0.902±0.003）明显低于对照组（0.914±0.003）（均P＜0.05）.重复测量的方差分析表明No-go刺激的ERP N2波幅在组间、前额电极位点以及组间×前额电极位点显示主效应（组间：F=3953,df=1,P=0.000;前额电极位点：F=541,df=9,P=0.000,组间×前额电极位点：F=306,df=9,P=0.000）;组间、头皮中心电极位点以及组间×头皮中心电极位点显示主效应（组间：F=9074,df=1,P=0.000;前额电极位点：F=163,df=9,P=0.000,组间×前额电极位点：F=73,df=9,P=0.000）;IAD N2波幅比对照组低.结论 IAD具有冲动控制障碍谱系的神经心理与ERP的特征,支持IAD是一种冲动控制障碍或与之相关疾病的假设.Objective To investigate deficient inhibitory control in individuals with IAD using a visual go/no-go task by ERPs. Methods 26 individuals met YDQ criteria for IAD were enrolled as research group and marched sexual and age 26 healthy person enrolled as control group. BIS-11 was used for measures of impulsivity.A go/no-go task involved eight different two-digit numerical stimuli. The response window was 1000 ms and the ITIwas 1500 ms. EEG was recorded during participants performed the task. BESA 5.2.0 was used to perform data analysis and the no-go N2 amplitude was analyzed for investigation of inhibitory control. Results BIS-11 total scores, attentional key scores and motor key in IAD group were higher than that of control group. In the go/no-go task, false alarm rate of IAD group was higher and hit rate was lower than that of control group. A repeated measure ANOVA revealed a significant group, frontal electrode sites and group × frontal electrode sites main effect for N2amplitudes of no-go conditions （ for group： F= 3953, df= 1, P= 0.000;for frontal electrode sites： F= 541, df= 9, P= 0.000;for group × frontal electrode sites： F = 306, df = 9, P = 0. 000 ）, and a significant group, central electrode sites and group × central electrode sites main effect for N2 amplitudes of no-go conditions （ for group： F=9074, df= 1, P = 0. 000;for central electrode sites： F = 163, df= 2, P = 0.000;for group × central electrode sites： F = 73, df= 2, P = 0.000）. N2 amplitudes of no-go conditions were lower than those at control group. Conclusions Individuals with IAD were more impulsive than controls and shared neuropsychological and ERPs characteristics of compulsive-impulsive spectrum disorder, which supports that IAD is an impulse disorder or at leastrelated to impulse control disorder.

关 键 词：视觉反应/不反应任务 冲动性 事件相关电位 网络成瘾 

分 类 号：R749.99[医药卫生—神经病学与精神病学]