顺铂腹腔注射联合化疗治疗晚期及复发型卵巢癌——4年回顾  

TREATMENT OF LATE AND RECURRENT CARCINOMA OF OVARY WITH COMBINED SYSTEMIC AND INTRAPERITONEAL INSTILLATION OF CISPLATINUM

作　　者：王中泰[1] 周郅隆[1] 

机构地区：[1]上海第二医科大学附属新华医院妇产科

出　　处：《上海医学》1990年第8期453-456,共4页Shanghai Medical Journal

摘　　要：本文对1985年1月～1988年10月间用顺铂腹腔注射联合化疗治疗晚期和复发型卵巢癌20例作一回顾分析。共治疗82个疗程,近期有效率达89.47％。目前存活≥3年3例,≥2年4例,≥1年1例,<1年5例。有5例在用顺铂腹腔注射后作第2次剖腹,未发现腹腔脏器有任何不良反应。文内对顺铂的剂量、用药方法、主要副反应,以及7例死亡原因作了讨论。Twenty patients with late or recurrent ovarian carcinoma were treated with combined systemic and intraperitoneal instillation of cisplatinum. The treatment regimen consisted of debulky operation first followed by 50-100mg/m^2 cisplatinum in 1000-1500ml lactate Ringer's solution instilled intraperitoneally once per course and cytoxan 6-8mg/kg/day and 5-FU 25-30mg/kg/day intravenous drip 5 times per course. In a few cases, intraperitoneal cisplatinum instillation was followed by oral melphalan 0.2mg/kg/day for 5 days per course. A total of 82 courses of combined treatment was given to the 20 patients with an effective rate of 89.4%. Three patients are living and well for more than 3 years, 4 more than 2 years, one more than one year and 5 less than one year. Five patients died within 1 year and one each dicd at 13 and 28 months respectively. Secondary laparotomy was performed in 5 patients following the intraperitoneal treatment and revealed no ill effect exerted on the peritoneal viscera. The dose of cisplatinum, method of application, main side effects and causes of fatalities are discussed.

关 键 词：卵巢肿瘤 癌 顺铂 药物疗法 

分 类 号：R737.310.5[医药卫生—肿瘤]