218例急性白血病流式细胞术免疫表型分析  

Analysis of Immunophenotype in 218 Cases with Acute Leukemia by Flow Cytometry

作　　者：赵皓[1] 余晾[1] 吕合作[1] 郑宏波[1] 项平[1] 

机构地区：[1]安徽省蚌埠医学院第一附属医院中心实验室,233004

出　　处：《中华全科医学》2010年第10期1239-1240,共2页Chinese Journal of General Practice

摘　　要：目的研究急性白血病(AL)免疫表型特征及诊断价值。方法采用流式细胞术(FCM)对218例初诊急性白血病患者进行免疫分型。结果急性髓系白血病(AML)患者均表达两种以上髓系抗原,其中部分伴有淋系抗原(CD7)表达。急性淋系白血病(ALL)患者均表达淋系抗原,部分表达一种或两种髓系抗原。14例混合型白血病同时表达两种以上淋系和髓系抗原标志。4例慢粒急淋变既表达髓系抗原又表达淋系抗原。结论 FCM免疫分型是在细胞形态学和细胞化学染色基础上对急性白血病诊断与分型的重要补充。Objective To explore the acute Leukemia immunophenotype and its diagnosis value.Methods Assay the immune phenotype in 218 patients with acute leukemia by flow cytometer.Results The patients with acute myeloid leukemia（AML） expressed more than two kinds of myeloid antigens;part of them expressed lymphatic antigens（CD7）.The patients with acute lymphoblastic leukemia（ALL） expressed lymphatic antigens;part of them expressed one or two kinds of myeloid antigens.Fourteen patients with mixed acute leukemia（MAL） showed two kinds or more lymphoid and myeloid antigens.Four patients with chronic granular differentiated to acute lymphatic leukemia not only expressed myeloid antigens but also expressed lymphatic antigens.Conclusion The immunophenotype by flow cytometry is the important supplementary to acute leukemia diagnosis and typing in morphology and cytochemical dyeing foundation.

关 键 词：急性白血病 免疫表型 流式细胞术 

分 类 号：R733.7[医药卫生—肿瘤] R446.63[医药卫生—临床医学]