转录因子Elf-1在上皮性卵巢癌中的表达及其意义  

The expression of transcription factor Eft-1 in epithelial ovarian cancer

作　　者：伞宁[1,3] 刘慧迪[1] 闫彦[1] 韩蕊娜[1] 曹雪峰[1] 温海霞[1] 李晓梅[2] 刘国艺[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,150081 [2]哈尔滨医科大学第三附属医院病理科,150040 [3]哈尔滨市卫生学校,150010

出　　处：《国际遗传学杂志》2010年第4期207-210,共4页International Journal of Genetics

基　　金：黑龙江省青年科学基金（QC07C63）;中国博士后基金（2005038209）

摘　　要：目的探讨转录因子Elf-1在上皮性卵巢癌中的表达及其临床意义，并探讨Elf-1与卵巢癌细胞增殖的相关性。方法收集31例上皮性卵巢肿瘤组织及3例正常卵巢组织标本，采用免疫组化S-P法测定Elf-1在上皮性卵巢癌中的表达并对其表达情况进行分析。结果在23例上皮性卵巢癌组织中Elf-1阳性表达15例（65．22％）。Elf-1的表达与组织学类型有关（χ2=6．54，P〈0．05），与患者的年龄、FIGO临床分期差异无统计学意义（χ2=0．25和0．08，P〉0．05）。Elf-1在上皮性卵巢癌中的表达与c-Fos在上皮性卵巢癌中的表达呈正相关（Kappar=0．39，P〉0．05）。结论Elf-1在上皮性卵巢癌组织中呈高水平表达，且与原癌基因c-Fos的表达呈正相关，提示Elf-1可能通过影响上皮性卵巢癌细胞的增殖而参与其发生和发展。Objectives To detect the expression of transcription factor Elf-1 in epithelial ovarian cancer（EOC） and to investigate its relationship to proliferation. Methods Ovarian tissues from 31 cases of ovarian tumors and 3 cases of normal tissues were collected. The expression of Elf-1 and e-Fos were determined by immunohistochemistry. Results Strong positive expression of Elf-1 was found in 15 out of 23 cases of EOC （65.22%）. Elf-1 expression was associated with histological type （χ2 =6.54,P 〈0. 05）, but not associated with age and FIGO stage （χ2 = 0. 25 and 0.08, respectively, P 〉 0. 05 ）. Elf-1 expression was positively correlated with the expression of c-Fos （ Kappar = 0. 39, P 〉0. 05 ）. Conclusion Elf-1 is highly expressed in EOC, and positively correlated with c-Fos expression, suggesting that Elf-1 might be involved in the development and progression of EOC through its impact on proliferation.

关 键 词：ELF-1 C-FOS 表达 上皮性卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]