雌激素受体与食管癌临床病理特性的关系  

Relationship between Expression of Estrogen Receptor and Clinical Pathological Features in Esophageal Squamous Cell Carcinoma

作　　者：曹巍[1] 常扶保 王慧珍 任秀花[4] 原志庆[1] 郑宗秀[1] 

机构地区：[1]新乡医学院,新乡453003 [2]河南省林县食管癌医院 [3]河南省新乡市中心医院 [4]河南医科大学

出　　处：《中国肿瘤》1999年第6期284-285,共2页China Cancer

基　　金：河南省自然科学基金!954020900

摘　　要：目的探讨雌激素受体表达与食管鳞状细胞癌临床病理的关系。方法用免疫组织化学方法检测了47例林县食管癌组织中ER的表达。结果47例食管癌标本中，ER阳性者19例，其表达率为40．4％（19／47）；生存期大于5年组与小于5年组相比，ER阳性率为28．6％和57．9％，具有显著性差异（P＜0．05），与性别、癌组织分化程度及有无淋巴结转移无关。结论食管癌可能是雌激素依赖性肿瘤，雌激素受体阳性的食管癌与雌激素受体阴性的食管癌相比，后者的预后较好。[Purpose] To ascertain relationship between clinical pathological features and estrogen receptor (ER). [Method] Immunohistochemical detection of ER was performed in 47 an of Linxian esophageal squamous cell carcinoma (ESCC). [Results] Positive ER was seen in 19 of the 47 patients with esophageal cancer (40.4% ). ER positive was 28. 6% in patient survival longer than 5 years , 57.9% in patient survival less than 5 yare. There was significant difference between the two groups (P < 0. 05.). However, there was no significant correlation with the sex , histologic grade, and lymphatic spread .[Conclusion] It is indicated that carcinogenesis of esophageal carcinoma might be related to sex hormone metablism . The results suggest that ER positive ESCC has worse pronosis than ER negative ESCC.

关 键 词：雌激素受体 免疫组织化学 食管肿瘤 预后 

分 类 号：R735.1[医药卫生—肿瘤]