吡美莫司的合成及其结构鉴定  

Synthesis and identification of pimecrolimus

作　　者：范丹[1] 温耀明[2,3] 陈秀明[2] 洪秀清[1] 郑卫[1,2] 

机构地区：[1]福建医科大学,福州350004 [2]福建省微生物研究所,福州350007 [3]福建省新药(微生物)筛选重点实验室,福州350007

出　　处：《海峡药学》2010年第8期245-247,共3页Strait Pharmaceutical Journal

摘　　要：以子囊霉素为原料,经酯化、氯化合成吡美莫司;粗品经柱层析、重结晶得到纯化,最终收率41.1%,纯度95.3%;合成产品经熔点,IR,1HNMR,13CNMR,ESI/MS等分析手段进行鉴定。Pimecrolimus was synthesized by using ascomycin as a starting material through esterification and chlorination. The pure products were obtained by columnchromatography and crystallization. （the finally yield was 41.1%, the purity was 95.3 % ） The structure was confirmed by melting point, IR, 1H NMR, 13C NMR and ESI/ MS analysis.

关 键 词：吡美莫司 合成 纯化 鉴定 

分 类 号：R914.3[医药卫生—药物化学]