2-氯-3,3′,4,4′,5-五甲氧基二苯甲酮的全合成及表征  

Total synthesis and characterization of 2-chloro-3,3’,4,4’,5-pentamethoxydiphenylmethanone

作　　者：冯秀娥[1] 赵万一[1] 李青山[1] 

机构地区：[1]山西医科大学药学院药物化学教研室

出　　处：《山西医科大学学报》2010年第8期703-704,共2页Journal of Shanxi Medical University

基　　金：国家“863”计划资助项目(2006AA09Z446);山西省回国留学人员科研资助项目(2008-51);山西省高等学校科技项目资助(200811011)

摘　　要：目的合成2-氯-3,3′,4,4′,5-五甲氧基二苯甲酮。方法以3,4,5-三甲氧基苯甲酸为原料,经酰氯化、傅克（Friedel-Crafts）酰化、氯代反应制备2-氯-3,3′,4,4′,5-五甲氧基二苯甲酮。结果产物结构经质谱（ESI-MS）、核磁共振氢谱和碳谱（1H-NMR、13C-NMR）进行了表征,反应总收率80%。结论本文首次全合成了新化合物2-氯-3,3′,4,4′,5-五甲氧基二苯甲酮,工艺合理可行、简单实用。Objective To synthesize 2-Chloro-3,3＇,4,4＇,5-pentamethoxydiphenylmethanone.Methods 2-Chloro-3,3＇,4,4＇,5-pentamethoxydiphenylmethanone was prepared from 3,4,5-trimethoxybenzoic acid by acylation,Friedel-Crafts acylation and chlorination.Results Products were characterized by ESI-MS,1H-NMR,and 13C-NMR.The overall yield was about 80%.Conclusion 2-Chloro-3,3＇,4,4＇,5-pentamethoxydiphenylmethanone was firstly totally synthesized from 3,4,5-trimethoxybenzoic acid.And the designed technology provides a simple,reasonable and practicable procedure for the synthesis of 2-chloro-3,3＇,4,4＇,5-pentamethoxydiphenylmethanone.

关 键 词：3 4 5-三甲氧基苯甲酸 2-氯-3 3′ 4 4′ 5-五甲氧基二苯甲酮 傅克酰化 氯代 

分 类 号：R914[医药卫生—药物化学]