血清N-乙酰-β-D-氨基葡萄糖苷酶在肝病诊断中的应用  

APPLICATION OF SERUM N ACETYL β D GLUCOSAMINIDASE DETERMINATION IN DIAGNOSIS OF LIVER DISEASES

作　　者：贾莉[1] 乔文涛[1] 

机构地区：[1]天津公安医院

出　　处：《中日友好医院学报》1999年第3期167-169,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的：观察血清Ｎ乙酰βＤ氨基葡萄糖苷酶（ＮＡＧ）活性对临床上几种肝病诊断的价值。方法：对１０３例肝病患者进行血清ＮＡＧ活性和血清总胆汁酸（ＴＢＡ）水平测定，并与传统肝功能试验做比较；选取１３０例健康体检者做血清ＮＡＧ活性参考值统计。所有项目均采用日立７１５０型自动生化分析仪测定。结果：健康人血清ＮＡＧ测值呈正偏态分布，以Ｐ９５作参考值上限为２１５Ｕ／Ｌ。血清ＮＡＧ在肝癌和酒精性肝病中阳性率分别为８００％和７００％，ＴＢＡ在肝硬变和急性肝炎中阳性率分别为９１６％和６８８％。结论：血清ＮＡＧ活性测定不仅对临床各种肝病的诊断有价值，而且其与血清ＴＢＡ同时检测能更有效地对急性酒精中毒和肝硬变进行早期鉴别诊断。Objective:To observe the value of activity of serum N acetyl β D glucosaminidase(NAG) in the clinical diagnosis of several liver diseases.Methods:We determined activity of serum NAG and level of serum total bile acid(TBA) in 103 patients with liver diseases,and the results were compared with traditional liver function tests.We also determined activity of serum NAG in 130 healthy individuals,and the results were used as reference values.All the tests were carried on by using HITACHI 7150 biochemical autoanalyzer.Results:The value of serum NAG in healthy individuals is positive skewness distribution with the upper threshold of reference value of P 95=21 5 U/L.The positive rate of NAG is 80 0% in liver cancer and 70 0% in alcoholic liver disease.The positive rate of TBA is 91 6% in cirrhosis and 68 8% in acute hepatitis.Conclusion:The determination of serum NAG is not only valuable for several liver diseases but also efficient and earlier for modifying acute alcoholism and cirrhosis when determined with serum TBA together.

关 键 词：肝疾病 氨基葡糖苷酶 胆汁酸类和盐类 

分 类 号：R575.104[医药卫生—消化系统]