男性癫痫患者服用抗痫药物后血清性激素水平改变及其临床意义  

Serum sexual hormonal changes and their clinical significance in male epileptic patients receiving antiepileptic therapy

作　　者：王雁[1] 谭兰[1] 唐盛孟[1] 

机构地区：[1]青岛医学院附属医院神经科

出　　处：《临床神经病学杂志》1999年第3期146-148,共3页Journal of Clinical Neurology

摘　　要：目的研究抗痫药物（ＡＥＤｓ）对男性癫痫患者性激素水平的影响。方法应用放射免疫分析法（ＲＩＡ）和免疫放射测定分析法（ＩＲＭＡ）测定应用多种ＡＥＤｓ治疗和未经治疗的男性癫痫患者及健康对照组血清睾酮（ＴＴ）、游离睾酮（ＦＴ）、性激素结合球蛋白（ＳＨＢＧ）、雌二醇（Ｅ２）、间质细胞刺激素（ＬＨ）、滤泡刺激素（ＦＳＨ）的水平。结果未治疗组与正常对照组相比，各项指标均无显著差异；各治疗组与对照组相比，ＦＴ水平均显著降低，ＳＨＢＧ水平显著升高；苯妥英钠治疗组的Ｅ２水平升高；而ＴＴ、ＬＨ、ＦＳＨ的水平各组间差别无统计学意义。结论ＡＥＤｓ可以影响男性癫痫患者性激素水平。Objective To study the effects of antiepileptic drugs(AEDs) on sex hormones in male epileptic patients. Methods Total testosterone (TT), free testosterone (FT), sex hormones binding globulin (SHBG), estradiol(E 2), LH and FSH were measured by radioimmunoassay (RIA) or immunoradiometric assay (IRMA) in male epileptic patients receiving antiepileptic therapy and in a control group, consisting of untreated patients and healthy subjects. Results There was no difference in all parameters between untreated group and control one. All therapeutic regimens were associated with low levels of serum FT and high serum concentrations of SHBG. E 2 was elevated in patients receiving PHT. Serum concentrations of TT,LH and FSH remained unchanged. Conclusion AEDs can affect the serum sexual hormonal levels in male epileptic patients.

关 键 词：癫痫 抗痫药物 性激素 治疗 

分 类 号：R742.105[医药卫生—神经病学与精神病学]