帕金森病发病危险因素的研究  

Clinical significance of eye movement abnormality in brain stem lesion

作　　者：张俊徽[1,2] 潘勇辉[1,2] 黎锦如 刘焯霖[1,2] 

机构地区：[1]广东医学院附属医院神经科 [2]中山医科大学第一附属医院神经科

出　　处：《临床神经病学杂志》1999年第3期155-157,共3页Journal of Clinical Neurology

摘　　要：目的探讨帕金森病（ＰＤ）发病的危险因素。方法利用病例对照研究方法对１００例ＰＤ患者和１００例年龄及性别相匹配的对照组进行分析，并对７２例ＰＤ和６６例对照者的载脂蛋白Ｅ（ａｐｏＥ）基因型进行检测。结果发现引起ＰＤ发病的危险因素包括不良环境暴露、幼年期的居住地、脑外伤、阳性家族史及农业劳动等；同时发现ａｐｏＥ等位基因频率在ＰＤ和本研究的对照组间分布无显著性差异。结论本研究支持在ＰＤ发病机制中环境因素比遗传因素可能更为重要。Objective To discuss the clinical significance of eye movement abnormality (EMA) in brain stem lesion. Methods EMA of 51 patients with brain stem lesions which were confirmed by means of cranial CT or MRI was analyzed . The relationship between EMA and site of brain stem lesion was observed. Results (1)In mesencephalon injury various eye position disorders are presented . Either vertical gaze palsy or convergence palsy is its own characteristics. (2) Horizontal EMA with spared vertical gaze paresis is the character in pontine lesion. (3) In medulla oblongata lesion all kinds of nystagmus are often seen .For localization we should refer to vertigo, vomiting and real bulbar paralysis.(4)Type of nystagmus is not very important in localization of brain stem lesion . Conclusion EMA had the value to the site diagnosis in brain stem lesion.

关 键 词：帕金森病 危险因素 流行病学 载脂蛋白E 

分 类 号：R742.501[医药卫生—神经病学与精神病学]