铁皮枫斗颗粒对放射性损伤小鼠存活情况及脾脏的影响  

Effect of Dendrobium Candidum Wall.Exlindl Drop on Survival Condition and Spleen of Mice with Radiation Injury

作　　者：秦秋荣[1] 张国庆[2] 

机构地区：[1]昆山市中医医院心内科,江苏昆山215300 [2]苏州大学附属第二医院,江苏苏州215004

出　　处：《苏州大学学报（医学版）》2010年第3期491-493,497,F0003,共5页Suzhou University Journal of Medical Science

摘　　要：目的研究铁皮枫斗颗粒(DCWD)对放射性损伤小鼠存活情况和脾脏病理组织学改变的影响。方法 BALB/c小鼠125只,随机分为对照组、单纯照射组及DCWD大、中、小剂量组。观察受照射小鼠的存活情况及脾脏HE染色病理组织学改变。结果受照射小鼠平均存活时间较对照组显著缩短(P<0.01),DCWD组较单纯照射组显著延长(P<0.01);照射后小鼠出现脾脏的急性放射性损伤;DCWD组病变程度较轻、恢复较快,但无明显的量效关系。结论 DCWD能明显延长受照小鼠平均存活时间,提高其存活率,减轻受照射小鼠脾脏的病理学改变程度,对放射性损伤具有一定的保护作用。Objective To study the effect of Dendrobium candidum Wall.exlindl drop（DCWD） on survival condition and pathological change of spleen of mice with radiation injury.Methods One hundred and twenty-five BALB/c mice were divided into the control group,irradiation-injured group and DCWD groups which were divided into three groups according to the dose of DCWD.The survival condition of irradiated mice and its pathological change of spleen were observed.Results The mean survival time of mice in each group irradiated with X-ray were shorter than that in the control group（P 0.01）,but in the DCWD groups survival is longer than that in the irradiation-injured group（P 0.01）.Acute radiation injury of spleen emerged.The pathological change degree was slight in the DCWD groups,and can recover quickly.But there was not conspicuous dose-effect relationship DCWD groups.Conclusion DCWD can prolong the mean survival time,improve the survival rate of irradiated mice,and relieve the degree of pathological change in spleen of mice with radiation injury;DCWD has certain protective effect on radiation-injury.

关 键 词：铁皮枫斗颗粒 放射性损伤 存活情况 脾脏损伤 

分 类 号：R57[医药卫生—消化系统]