肥胖儿童血清维生素D、甲状旁腺素及胰岛素抵抗水平分析  

Analysis on levels of serum vitamin D,parathyroid hormone and insulin resistance in obese children

作　　者：杨芳[1] 吕学云[2] 张军生[2] 程玉先[2] 张传霞[1] 

机构地区：[1]山东省聊城职业技术学院,山东聊城252000 [2]山东省聊城市人民医院儿科

出　　处：《中国妇幼保健》2010年第24期3417-3419,共3页Maternal and Child Health Care of China

基　　金：2008年度山东省高等学校优秀骨干教师国际合作培养项目

摘　　要：目的:分析肥胖儿童血清VD、PTH及胰岛素抵抗水平,探讨肥胖与上述指标的关系。方法:在健康体检时,利用体重指数(BMI),以中国肥胖工作组制定的标准进行筛查,将研究对象分为肥胖组与对照组,采集空腹静脉血分别测定25(OH)D、1,25(OH)2D、PTH、血钙、磷和碱性磷酸酶(AP),测定FINS和FPG计算HOMA-IR,测定身高、体重计算BMI。结果:肥胖组VD缺乏率明显高于对照组。与对照组相比,肥胖儿童的BMI、PTH和HOMA-IR明显升高,VD水平明显降低(P<0.05)。BMI与血清VD呈明显负相关,与PTH和HOMA-IR呈明显正相关。PTH与25(OH)D呈明显负相关,与HOMA-IR呈明显正相关;25(OH)D与HOMA-IR呈明显负相关。结论:肥胖儿童血清VD水平降低,PTH增高,胰岛素抵抗增强。肥胖与VD、PTH和HOMA-IR相关,PTH、25(OH)D与HOMA-IR分别相关。Objective：To analyze the levels of serum vitamin D,parathyroid hormone （PTH） and insulin resistance in obese children,explore the relationship between obesity and the above indexes.Methods：The research objects receiving physical examination were screened by body mass index （BMI） according to criteria established by China Obesity Workgroup,then they were divided into obesity group and control group,the fasting venous blood samples were taken to detect the levels of 25（OH）D,1,25（OH）2D,PTH,blood calcium,phosphate and alkaline phosphatase （AP）,FINS,FPG,then HOMA-IR was calculated,body height and body weight were measured to calculate BMI.Results：The rate of vitamin D deficiency in obesity group was significantly higher than that in control group;compared with control group,BMI,PTH and HOMA-IR increased and the level of vitamin D decreased significantly in obesity group （P0.05）;there was a negative correlation between BMI and serum vitamin D,while there was a positive correlation between BMI and PTH,HOMA-IR;there was a negative correlation between PTH and 25（OH）D,there was a positive correlation between PTH and HOMA-IR,there was a negative correlation between 25（OH）D and HOMA-IR.Conclusion：The decrease of serum vitamin D level,increase of PTH and enhancement of insulin resistance exist in obese children;there is a correlation between obesity and vitamin D,PTH,HOMA-IR;PTH and 25（OH）D are correlated with HOMA-IR,respectively.

关 键 词：VD PTH HOMA-IR 肥胖儿童 

分 类 号：R153.2[医药卫生—营养与食品卫生学]