克氏综合征患者性激素水平分析  

Analysis of serum sex hormone level in Klinefelter syndrome

作　　者：汤丽霞[1] 杨光[1] 禤洁甜[1] 梁彩红[1] 林蔚[1] 陈华锦[1] 

机构地区：[1]广东省佛山市第一人民医院临床研究所,528000

出　　处：《重庆医学》2010年第17期2330-2331,共2页Chongqing medicine

摘　　要：目的分析血清雌二醇(E2)、促卵泡激素(FSH)、黄体生成素(LH)、睾酮(T)水平变化规律对快速筛查诊断克氏综合征(KS)患者的应用价值。方法染色体核型分析KS患者22例为实验组,正常核型男性不育患者20例为对照组。所有患者均为雄性激素治疗前进行精液分析及血清性激素水平检测。结果实验组FSH和LH两项指标同时增高占100%,对照组占5%。以FSH和LH两项同时升高为筛查KS患者的诊断指标,其敏感性可达100%,特异性可达97.5%。实验组81.8%的患者血清睾酮水平降低。结论 FSH和LH两项指标同时升高是KS患者血清性激素变化的主要特征,FSH和LH两项同时升高可作为筛查诊断KS患者的指标。Objective To investigate the regularity of the serum concentrations of testosterone（T）,estradiol（E2）,follicle stimulating hormone（FSH）and luteinizing hormone（LH） for rapid screening method to diagnose Klinefelter syndrome（KS）.Methods 42 infertile males were studied by retrospective analysis.There were 22 out of them with KS as the experimental group and 20 with the male infertile of 46,XY karyotype as control group.Before the treatment of androgen hormone the semen samples were analyzed according to the current World Health Organization Laboratory Manual（World Health Organization,1999） and the sex hormones were detected with chemo-luminescence immune assay.Results Both FSH and LH increasing simultaneously accounted for 100% in KS group and 5% in normal control group.The sensitivity was up to 100% and the specificity was up to 97.5% if combining FSH with LH served together as screening criterion of KS.The serum concentration of testosterone decreased in 81.2% of patients in KS group and for 10% in control group.There was normal level of testosterone in KS group accounting for 18.2%.Conclusion The elevation of FSH and LH level are the peculiar to KS.Both of FSH and LH as screening criterion of KS presents highly the sensitivity and the specificity.The mean value of the serum concentration of testosterone is obvious lower in KS patients.However,not in all of patients there is lower level of serum testosterone concentration in KS group.

关 键 词：克氏综合征 性激素 筛查 

分 类 号：R698.2[医药卫生—泌尿科学]