乳腺癌患者预后及病理因素与FAT10 mRNA表达的相关性  

Expression and Clinical Significance of FAT10 in Breast Cancer

作　　者：李志红[1,2] 王志明[1] 方力[2] 

机构地区：[1]中南大学湘雅医院普通外科,湖南长沙410008 [2]郴州市第一人民医院普通外科

出　　处：《南华大学学报（医学版）》2010年第5期620-623,共4页Journal of Nanhua University(Medical Edition)

摘　　要：目的探讨乳腺癌组织中FAT10 mRNA的表达与乳腺癌患者病理因素及预后的相关性。方法收集67例乳腺癌术后患者资料,采用RT-PCR方法检测乳腺癌组织、癌旁组织和正常乳腺组织中FAT10 mRNA的表达情况,并分析该基因表达对乳腺癌患者临床病理因素及预后的影响。结果 FAT10 mRNA在本组乳腺癌中阳性表达率为52.24%(35/67),在乳腺癌组织中的表达明显高于癌旁组织和正常乳腺组织(P<0.05),FAT10mRNA的表达与淋巴结转移和TNM分级密切相关(P<0.05),而与患者的年龄、肿瘤大小、肿瘤分化程度等无关(P>0.05)。FAT10阳性表达者生存率明显低于阴性者(P<0.05)。结论 FAT10在乳腺癌组织表达状态与乳腺癌的转移及预后关系密切,可以作为反映乳腺癌生物学行为和判断预后的有效指标。Objective To investigate the relationship between expression of FAT10 in breast cancer and its clinicopathologic significance. Methods 67 cases of the breast cancer patients in 2001～2004 in our hospital were collected,using RT-PCR to detect breast cancer tissue and normal breast tissue in FAT10 mRNA expression,and the relation of FAT10 expression with clinicopathological features and clinical outcomes of breast cancer patients were analyzed.Results The intensive positive rate of FAT10 expression in breast cancer was 52.24%（35/67）.Expression of FAT10 was highly correlated with lymph node metastasis and T classification（P 0.05）,but not with age,tumor size,clinical stage and tumor differentiation,etc.（P0.05）.In the intensive positive rate of FAT10 expression in breast cancer,the survival rate was significantly lower than negative ones（P0.05）. Conclusion Overexpression of FAT10 in patients with breast cancer enhances the possibility of invasion and metastasis,implying a poor prognosis.FAT10 may serve as a fairly good prognostic factor to indicate biologic behavior and prognosis in breast cancer.

关 键 词：FAT10 乳腺癌 预后 

分 类 号：R737.9[医药卫生—肿瘤]