咖啡因体内代谢及其应用的研究进展  

Progress in the Research of Caffeine Metabolism and Its Application in Vivo

作　　者：陈尧[1] 周宏灏[1] 

机构地区：[1]中南大学临床药理研究所

出　　处：《生理科学进展》2010年第4期256-260,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金资助课题(30572226)

摘　　要：咖啡因是从茶叶、咖啡果中提取出来的一种生物碱,常用于治疗神经衰弱和昏迷复苏。咖啡因体内代谢过程复杂,现已发现咖啡因的15种代谢产物,参与代谢过程的酶类也被逐一证实。尿液咖啡因代谢产物比率（UCMRs）常用于多种药物代谢酶活性的评估,主要包括CYP1A2、CYP2A6、N-乙酰转移酶和黄嘌呤氧化酶,咖啡因及其代谢产物检测方法也逐步得到改进与更新。总之,咖啡因与人类健康密切相关,以及其重要的科研应用价值,一直受到普遍关注。Caffeine,a kind of alkaloid,extracted from tea and coffee fruit,is commonly used in the treatment of neurasthenia and for coma recovery.The metabolic process of caffeine in vivo is complex.Fifteen kinds of metabolites have been found,and the enzymes involved in the metabolic processes have also been confirmed.The urinary caffeine metabolites ratios are commonly used in the assessment of activities of drug metabolizing enzymes,mainly including CYP1A2,CYP2A6,N-acetyltransferase and xanthine oxidase.Methods for detection of caffeine and its metabolites have been improved steeply.In brief,caffeine has been paid close attention due to its intimate connection with human health as well as its importance in application in scientific research.

关 键 词：咖啡因 药物代谢 代谢酶 

分 类 号：R969[医药卫生—药理学]