一种新型稠合双环氮杂环丙烷衍生物开环反应研究  

The Regioselective Ring Opening Reaction of a New Type Bicyclic Fused Aziridines

作　　者：郭鹏[1] 裴强[1] 范爽[1] 张小宁[1] 

机构地区：[1]信阳师范学院化学化工学院,河南信阳464000

出　　处：《信阳师范学院学报（自然科学版）》2010年第3期455-457,共3页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(20805040)

摘　　要：以醇为溶剂、微量的浓硫酸为催化剂、稠合双环氮杂环丙烷衍生物为底物,通过亲核取代反应将氮杂三环打开,合成了2个新的开环产物.用IR、^1H NMR、^13C NMR、EIMS、元素分析等手段对新化合物进行了结构表征.该方法操作简单,醇既是溶剂又是亲核试剂,产率较高（78%-83%）.Bicyclic fused aziridines can generate regioselective ring opening reaction with various alcohols,catalyzed by small amount of concentrated sulfuric acid.Two new ring-opening products were obtained and characterized with IR,^1H NMR,^13C NMR and EIMS.In this reaction,alcohols are not only nucleophiles but also solvents.This method provides several advantages such as high yield（78%～83%）,simple work-up procedure,shorter reaction time,milder conditions.

关 键 词：氮杂环丙烷衍生物 开环反应 亲核基团 

分 类 号：O621.3[理学—有机化学]