胃黏膜癌变过程中环氧合酶-2和C-met蛋白的表达及其意义  

Expression and significance of cyclooxygenase-2 and C-met protein in carcinogenesis of gastric mucosa

作　　者：来玉红[1] 吕增华[1] 

机构地区：[1]滨州医学院附属医院病理科,滨州256603

出　　处：《解剖学杂志》2010年第4期443-445,454,共4页Chinese Journal of Anatomy

摘　　要：目的： 探讨环氧合酶-2 （COX-2）和C-met蛋白在胃黏膜癌变过程中的变化规律及其意义.方法：采用Envision法,用20例慢性浅表性胃炎作为对照组,对38例慢性萎缩性胃炎伴肠上皮化生、38例肠化伴异型增生和76例胃腺癌标本,分别检测COX-2和C-met蛋白的表达情况,并分析其间的相关性.结果： C-met蛋白在慢性浅表性胃炎组的表达低于其他胃黏膜病变组织;从非萎缩性胃炎胃黏膜组织→肠化生→异型增生→胃癌,COX-2的表达逐渐增高.COX-2与C-met蛋白的表达呈正相关.结论： 细胞增殖和凋亡相关因子C-met蛋白与COX-2表达异常在胃黏膜癌变过程中发挥重要作用.Objective： To investigate the expression and significance of cyclooxygenase-2 （COX-2） and C-met protein in the carcinogenesis of gastric mucosa. Methods： Twenty chronic superficial gastritis, 38 chronic atrophic gastritis with intestinal metaplasia, 38 intestinal metaplasia with dysplasia and 76 gastric cancer were collected. The expression of COX-2 and C-met protein in those tissues was determined by Envision irnmunohistochemieal technique, and the relationship between COX-2 and C-met was analyzed. The results were analysed by SPSS 13.0. Results： The expression of C-met protein in normal gastric mucosa was the lowest among the various gastritis from the non-atrophic gastric mucosa, dysplasia to gastric cancer. There was a positive correlation between the expression of COX-2 and C-met protein. Conclusion： COX-2 and C-met protein may play an important role in the carcinogenesis of gastric mucosa.

关 键 词：萎缩 化生 异型增生 胃肿瘤 环氧合酶-2 C-MET 蛋白 

分 类 号：R737.31[医药卫生—肿瘤]