涎腺肌上皮瘤19例临床病理学分析  

Clinicalpathological analysis of salivary gland myoepithelioma in 19 cases

作　　者：罗志飞[1] 郭峻莉[1,2] 

机构地区：[1]海南医学院病理学教研室,海南海口571101 [2]海南省热带病重点实验室,海南海口571101

出　　处：《海南医学》2010年第16期110-111,共2页Hainan Medical Journal

基　　金：海南医学院苗圃基金项目(编号:209014)

摘　　要：目的探讨涎腺肌上皮瘤的临床病理学特征、免疫表型和鉴别诊断。方法收集19例涎腺肌上皮瘤患者资料,观察其临床病理学特征并进行免疫组化染色观察。结果肿物直径1.2-5.0cm不等,发生于腮腺13例,腭部4例,颌下腺2例。免疫组化结果显示肌上皮瘤表达Calponin(100%)、S-100(94.7%)、SMA(73.7%)、CK(94.7%)GFAP阳性(78.9%)。结论肌上皮瘤是良性涎腺肿瘤,临床表现不典型,镜下瘤细胞形态复杂多样,容易误诊,鉴别诊断必须依据组织学和免疫表型综合判断。Objective To investigate the clinical pathological characteristics,immunophenotype,and differential diagnosis of the myoepithelioma of salivary gland.Methods The clinical and pathological data of 19 patients with myoepithelioma of salivary gland were analyzed by immunohistochemistry and clinical pathological characteristics.Results Of the salivary gland myoepithelioma,the diameters were between 1.2 cm and 5.0 cm,and 13 cases were occurred in the parotid gland,4 cases in the palate and 2 cases in the submandibular gland. The percentage of positive expression of Calponin,S100,SMA,CK and GFAP protein were 100%,94.7%,73.7%,94.7% and 78.9% respectively.Conclusion Myoepithelioma of salivary gland tumors are benign with atypical clinical manifestations. As the tumor cells form under microscope is complex and diverse,it is easily misdiagnosed. The morphology and immunnohistochemistry is very pivotal and useful for differential diagnosis of myoepithelioma.

关 键 词：肌上皮瘤 涎腺 免疫组织化学 病理诊断 

分 类 号：R730.261[医药卫生—肿瘤]