伏隔核毁损治疗难治性精神分裂症的临床分析  

Treatment of intractable schizophrenia with nucleus accumbens damage techniques

作　　者：匡卫平[1] 黄红星[1] 郭田生[1] 蔡溢[1] 李波[1] 朱勇[1] 周彬[1] 陈小峰[1] 

机构地区：[1]湖南省脑科医院神经外科,长沙410007

出　　处：《中国实用神经疾病杂志》2010年第15期12-14,共3页Chinese Journal of Practical Nervous Diseases

基　　金：湖南省医药卫生科研课题;编号2005145

摘　　要：目的探讨伏隔核(nucleus accumbens,NAC)毁损手术治疗难治性精神分裂症的可行性和安全性。方法该组先后采用CT或MRI扫描定位,脑立体定向手术,行双侧伏隔核射频毁损治疗。结果近期有效率90.70%,无严重的并发症和后遗症,智能、记忆及神经心理测验有明显提高。结论脑立体定向伏隔核射频毁是治疗难治性精神分裂症的安全有效方法,围手术期配合有针对性的心理治疗,药物及康复治疗等,使脑立体定向手术效提高,术后复发和一次治疗无效的患者可以再次手术。Objective To approach feasibility and security of nucleus accumbens damage techniques treats intractable schizoprenia. Methods One hundred and twenty-six patients of intractable schizophrenia were scanned position by CT or MRI,were treaded with stereotactic surgery. The results were compared with CGI, BPRS, and SAPS, WISC scoring and neuropsychological tests before and after surgery. Results The efficient of recent period was 90. 7%. There wasn＇t serious complications and sequelae, WISC scoring, memory and neuropsychological tests were improved. Conclusion The stereotactic technique provides significant methods in intractable schizophrenia. But recovery needs combing psychotherapy, drug and function trained after operation.

关 键 词：立体定向手术 精神分裂症 伏隔核 

分 类 号：R749.3[医药卫生—神经病学与精神病学]