胸腺肽对心理应激引起老年大鼠免疫功能降低的改善作用  

THE EFFECTS OF THYMOPEPTDUM ON STRESS-INDUCED IMMUNITY IMPAIRMENT OF OLD RATS

作　　者：王会艳[1] 肖健[1] 耿晓峰[1] 苏彦捷[1] 

机构地区：[1]北京大学心理学系,北京100871

出　　处：《心理学报》1999年第3期330-336,共7页Acta Psychologica Sinica

摘　　要：研究胸腺肽作为一种免疫增强剂，是否参与调节应激对免疫系统的作用。心理应激采用可控／不可控电击的模型。结果表明，受到6天、每天半小时的可控或不可控的足底电击后，与不受电击的对照组相比，不可控组老年大鼠的免疫功能明显下降，而可控组没有明显变化；肾上腺糖皮质激素的分泌量在受到电台后显著升高。这两个事实说明长期应激对免疫系统造成了破坏作用。腹腔注射胸腺肽（共6次，隔日一次）能颉抗这种变化，改善应激情况下老年大鼠的体液免疫功能，并抑制肾上腺糖皮质激素的上升趋势，说明胸腺肽具有明显的抗应激和抗衰老的作用。The thymopeptdum is a well-characterized immunopotentiating hormone, thepresent experiments were designed to study whether thymopeptdum modulated theimmune system as an antistress factor. The controllable/uncontrollable footshock wereused as psychological stress. After 6 times of footshocks, 0.5hr per session, thehumoral immunity of uncontrollable old rats decreased signiflcantly, while the humoralimmunity of controllable rats was not significantly changed comparing to the controlgroup. The levels of glucocorticoid hormone of the two stress groups increasedheavily. The stressor controllability had influence on the levels of sertun IgG of rats.However, every other day for 6 times inhaperitoneally injections of thymopeptdumantagonized these changes, it improved humoral immunity of stressed fats, suppressedthe ascending trend of glucocorticoid hormone. The above mentioned resultsdemonstrated the thymopeptdum had antistress and antisenility effect.

关 键 词：胸腺肽 心理应激 抗衰老 心理神经免疫学 

分 类 号：B845[哲学宗教—心理学] R363.27[医药卫生—病理学]