多发性硬化患者认知障碍  

Cognitive impairment in patients with multiple sclerosis

作　　者：李莉莉[1] 张星虎[2] 

机构地区：[1]北京市垂杨柳医院神经内科,北京100022 [2]首都医科大学附属北京天坛医院神经内科,北京100050

出　　处：《中国实用神经疾病杂志》2010年第17期14-16,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的对MS患者认知情况进行评价,初步探讨MS患者认知障碍的发生频率、特点以及认知障碍对MS患者生活质量的影响。方法 28例复发缓解型多发性硬化患者,所有患者进行神经心理评价、临床功能障碍评价(EDSS)和生活质量评价(ADL和IADL),观察多发性硬化患者认知障碍发生情况,分析它们与其他临床表现相关关系,及各因素对认知的影响。结果患者中有认知障碍占71.4%(20/28),其中韦氏成人(或儿童智力)量表测查,全量表智商(FIQ)低于正常(<90分)为60.7%(17/28),临床记忆量表检查:记忆商(MQ)低于正常(<90分)为64.3%(18/28)。有认知障碍与无认知障碍2组间比较:受教育时间差异有统计学意义(P<0.01)回归分析发现EDSS、受教育时间对FIQ的影响以及年龄对MQ的影响有显著性意义。结论 MS患者有较高认知功能损害发生率,神经功能缺损与之相关。Objective To evaluate the cognitive impairment, and to disscuss the frequence, characteristic and machanism of congnition disorder inpatients with multiple sclerosis. Methods Twenty-eight patients with remitting-relapsing multiple sclerosis were recruited. All of them underwent Wechsler intelligence tests and clinical memory scale, and HAMD, HAMA, EDSS, ADL and IADL were used to assess the degree of cognition and affective disorder. We observed the incidence rate of cognitive disorder and analyzed their correlation with the clinical manifestation. Results Twenty patients （71.4%） had cognitive disorder, and 17 （60.7%） patients＇ full intelligence quotient （FIQ） and 18 （64.3 % ） patients＇ memory quotient （MQ） were abnormal. The proportion of cognitive disorder had significant difference （P〈0.01） between high education and low education patients. We found that EDSS and education time had a significant influence to FIQ. Age had a significant influence to memory quotient. Whether using methylprednisolone （oral or infusion） therapy had no significant influence to the degree of cognitive impairment. Conclusion Cognitive impairment has a high incidence rate in MS patients, and has a correlation with neurologic impairment.

关 键 词：多发性硬化 认知障碍 

分 类 号：R744.51[医药卫生—神经病学与精神病学]