阿托伐他汀治疗冠心病合并短暂脑缺血发作的临床疗效观察  

Effect of atorvastatin on coronary heart disease combined with transient ischemic attacks

作　　者：周向东[1] 万大国[2] 史改景 

机构地区：[1]河南渑池县人民医院,渑池452400 [2]郑州大学第二附属医院,郑州450014

出　　处：《中国实用神经疾病杂志》2010年第17期29-30,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察阿托伐他汀对冠心病合并短暂脑缺血发作的临床疗效。方法选择本院2007-09～2009-09门诊及住院符合TIA诊断标准及既往有冠心病病史的患者共108例,随机分为观察组和对照组各54例。2组患者均采取内科治疗,观察组口服阿托伐他汀20mg,1次/d,30d为1个疗程。对照组不服用降脂药。观察患者的临床疗效,比较治疗前后全血黏度、血浆黏度、红细胞比积、纤维蛋白原的变化。结果 2组患者治疗前后全血黏度、血浆黏度、红细胞比积、纤维蛋白原的变化差异有统计学意义。2组患者的显效率和总有效率差别有显著性意义(P<0.05),治疗组优于对照组。结论阿托伐他汀可以显著提高冠心病合并TIA患者的临床疗效,是一种有效的治疗方法。Objective To observe the clinical therapeutic effect of atorvastatin on coronary heart disease （CHD） combined with transient ischemic attacks （TIA）. Methods One hundred and eight patients who were consistent with the diagnostic criteria of TIA and had CHD in the past were chose in our hospital from September 2007 to September 2009, and they were randomly divided into observation group（54 cases） and control group（54 cases）. Patients in two groups were given medical treatment, at the same time, patients in observation group were treated with atorvastatin（20 mg/d, po ） for 30 days and patients in control group were not given atorvastatin. Clinical therapeutic effect was observed and the changes of whole blood viscosity, plasma viscosity, HCT and fibrinogen before and after treatment were compared. Results There were significant differences between two groups on whole blood viscosity, plasma viscosity, HCT and fibrinogen before and after treatment. There were significant differences between two groups in excellence rate and total effective rate （P〈0.05）. The effect was better in observation group than that in control group. Conclusion Atorvastatin can obviously increase the clinical therapeutic effect on patients of CHD combined with TIA, which is an effective therapeutic method.

关 键 词：阿托伐他汀 短暂脑缺血发作 冠心病 

分 类 号：R743.31[医药卫生—神经病学与精神病学]