原发性肝细胞癌手术患者的病因分析  

Analysis of the etiology of the operated patients with hepatocellular carcinoma

作　　者：陈漫霞[1] 姚振江[1] 王漫云[2] 陈思东[1] 许雅[1] 

机构地区：[1]广东药学院公共卫生学院,广州510310 [2]中山大学附属第二医院

出　　处：《公共卫生与预防医学》2010年第4期31-33,共3页Journal of Public Health and Preventive Medicine

基　　金：广东省自然科学基金(项目编号:07117591)

摘　　要：目的探讨原发性肝细胞癌（primary hepatocellular carcinoma,PHC）手术患者的人口学、乙型肝炎病毒（HBV）感染及其临床特征。方法通过查阅病历,获取原发性肝细胞癌手术患者的临床资料进行描述性分析。结果 PHC高发年龄为41~60岁（占55.17%）;以男性居多（占88.51%）;患者吸烟率、饮酒率和肿瘤家族史分别为48.56%、35.34%和16.09%;HBsAg阳性率为87.64%,感染模式以HBsAg、抗-HBe、抗-HBc三项阳性为多见（占53.16%）;血清AFP水平升高者占65.81%,AST升高者占61.21%,ALT升高者占48.28%,γ-GGT升高者占69.83%,伴有肝硬化者占67.53%。结论 PHC患者以中老年男性为主,其发生与HBV感染关系密切,患者吸烟、饮酒、肿瘤家族史比例较高;对有HBV感染、年龄41~60岁人群,定期体检对肝癌及早发现有重要意义。Objective To explore the demographic,hepatitis B virus infection and clinical characteristics of the operated patients with primary hepatocellular carcinoma（PHC）.Methods The clinical data of patients with PHC were analyzed descriptively.Results The highest incidence of HCC age range was 41-60 years（55.17%）.The percentage of male patients was 88.51%.The percentage of smoking,alcohol drinking and family history of liver tumor was 48.56%,35.34%,16.09% respectively.The positive rate of HBsAg was 87.64%.The positive rate of the combination of HBsAg,Anti-HBe and Anti-HBc was the highest（53.16%）.The elevated serum level of AFP,AST,ALT and γ-GGT were 65.81%,61.21%,48.28% and 69.83% respectively.The proportion of PHC patients with cirrhosis was 67.53%.Conclusions Patients with PHC were mainly middle-aged males,PHC was closely related with HBV infection.The proportion of those with smoking,alcohol drinking,HBV infection,family history of liver tumor,were relatively higher.It is very important to have regular physical examination in people ranged from 41 to 60 with HBV infection for the early discovery of HCC.

关 键 词：原发性肝细胞癌 流行病学 乙型肝炎病毒 

分 类 号：R735.7[医药卫生—肿瘤]