抗病毒口服液中挥发油羟丙基-β-环糊精包合物的稳定性考察  

Study on the Preparation and Stability of Volatile Oils HP-β-CD Inclusion Complex of Kangbingdu Oral Solution

作　　者：陈航[1] 邓丽明[2] 

机构地区：[1]江苏省食品药品检验所,南京210008 [2]东南大学附属中大医院药剂科,南京210009

出　　处：《药学与临床研究》2010年第4期408-410,共3页Pharmaceutical and Clinical Research

摘　　要：采用饱和水溶液法制备挥发油包合物,并以挥发油含量为测定指标,考察抗病毒口服液中挥发油羟丙基-β-环糊精包合物的稳定性。结果在光、热、湿等因素影响下,包合物中挥发油的含量没有明显变化,挥发性实验结果表明,包合物的热失重百分率比混合物小。即该包合物的稳定性明显优于单纯挥发油。Inclusion complex of volatile oils of Kangbingdu oral solution with 2-hydropropyl-β-cy-clodextrin（HP-β-CD） was prepared by a saturated water solution method and its stability was tested by determining the content of inner volatile oils included in the complex.Under different conditions such as light,heat and humidity,the content of volatile oils in inclusion complex had no obvious change.In the volatility test,the inclusion complex had less weight loss than that of the mixture of oil and HP-β-CD.That is,the prepared inclusion complex has superior stability than that of the oils without inclusion.

关 键 词：抗病毒口服液 挥发油 羟丙基-Β-环糊精 稳定性 

分 类 号：R927.11[医药卫生—药学]