SEMA3B基因与辐射相关信号通路的研究进展  

Research progress on SEMA3B and related signal pathways of ionizing radiation

作　　者：陈赟[1] 刘海燕[1] 尹小祥[1] 张昊文[1] 马燕[1] 刘芬菊[1] 

机构地区：[1]苏州大学医学部放射医学与公共卫生学院,苏州215123

出　　处：《辐射研究与辐射工艺学报》2010年第4期197-200,共4页Journal of Radiation Research and Radiation Processing

基　　金：国家自然科学基金(30870585);江苏省研究生培养创新工程项目(苏教研[2010]6号)资助

摘　　要：SEMA3B基因通过NP-1受体介导抑制PI3K/Akt传导通路,从而抑制PI3K/Akt对电离辐射所致DNA损伤的修复作用,增强了辐射对肿瘤细胞的杀伤作用;除此之外,SEMA3B通过竞争相同的NP受体抑制VEGF165的表达,减少VEGF165对电离辐射所致血管损害的保护作用,增加肿瘤的辐射敏感性。SEMA3B could sensitize tumor cells to radiation treatment through the way of inhibiting PI3K/Akt pathway,which could function as enhancing the repair of DNA damage induced by ionization radiation. Also,SEMA3B could enhance tumor radio-sensitivity by competing for binding VEGF165 to Neuropilin,which are the same receptors that they share,so as to inhibit the expression of VEGF165 which could protect the ionization radia-tion injury of blood vessels.

关 键 词：SEMA3B PI3K/AKT VEGF165 电离辐射 辐射敏感性 

分 类 号：R730.2[医药卫生—肿瘤] R730.55[医药卫生—临床医学]