β-环糊精超声包合广藿香挥发油的工艺研究  

Ultrasonic-induced preparation of the inclusion complex of herba pogostemonis volatile oil with β-cyclodextrin

作　　者：黄敏[1] 黄艳仙[1] 蒋达洪[1] 周建敏[1] 程钰成[1] 周如金[1] 

机构地区：[1]茂名学院化学与生命科学学院,广东茂名525000

出　　处：《安徽大学学报（自然科学版）》2010年第4期86-90,共5页Journal of Anhui University(Natural Science Edition)

基　　金：广东省自然科学基金资助项目(5300953)

摘　　要：考察广藿香挥发油β-环糊精包合物的制备工艺条件.以包合物的包合率作为评价指标,选择挥发油与β-CD的比例、包合温度、超声时间为主要影响因素,进行L9(34)正交试验,优化广藿香挥发油包合物的工艺条件.同时将广藿香挥发油β-环糊精包合物进行表征.结果表明:最佳包合工艺条件为挥发油与β-CD之比为1∶5、超声时间为45 m in、包合温度为50℃.在此条件下广藿香挥发油包合物的包合率可达80.9%.表征结果表明,广藿香挥发油β-环糊精包合物已经形成.因此,超声法制备广藿香挥发油的β-环糊精包合工艺合理可行.The process research for the preparation of inclusion complex of herba pogostemonis volatile oil with β-cyclodextrin was reported.The ratio between volatile oil and β-cyclodextrin,as well as the ultrasonic reaction time and the inclusion temperature was optimized by using the inclusion percentage as measurement through L9（34） orthogonal experiment.Meanwhile,the inclusion complex of herba pogostemonis volatile oil with β-cyclodextrin was characterized,an inclusion of 80.9% was obtained,with 1∶5 as the ratio between volatile oil and β-cyclodextrin,with 45 min as ultrasonic reaction time and with 50℃ as inclusion temperature.The formation of inclusion complex of herba pogostemonis volatile oil with β-cyclodextrin was confirmed by characterization.The results displayed that it was feasible to prepare inclusion complex of herba pogostemonis volatile oil with β-cyclodextrin through ultrasonic method.

关 键 词：广藿香 挥发油 Β-环糊精 包合物 表征 

分 类 号：R943[医药卫生—药剂学]