MicroRNA,lncRNA与神经退行性疾病  

MicroRNA and lncRNA in Neurodegenerative Diseases

作　　者：黄文涛[1,2] 郭向前[3] 戴甲培[1,2] 陈润生[3] 

机构地区：[1]中南民族大学电子信息工程学院,武汉430074 [2]中南民族大学,武汉神经科学和神经工程研究所,武汉430074 [3]中国科学院生物物理研究所,北京100101

出　　处：《生物化学与生物物理进展》2010年第8期826-833,共8页Progress In Biochemistry and Biophysics

基　　金：中南民族大学自然科学基金(YZZ09004);神经科学和神经工程重点实验室研究基金资助项目(XJS09001)~~

摘　　要：综述了microRNA和lncRNA在一些神经退行性疾病病理生理中的作用机制.随着社会生产的发展,人类文明的进步,人口日益老年化,神经退行性疾病正在全球范围内流行,严重地危害着人类的健康.尽管长期的研究使人们对神经退行性疾病有了比较全面和深入的了解,但是其背后隐藏的发病机制仍然是个谜.人类基因组约98%的转录产物为非编码RNA(ncRNA),在生命活动中有着许多鲜为人知的广泛而多样性的生物功能.小分子RNA(microRNA)是研究得相对比较深入的一类小ncRNA,最近2～3年,长非编码RNA(lncRNA)受到人们的重视,已积累了一些相关研究成果。With the development of social production,the progress of human civilization,and the growing aging population,neurodegenerative diseases are a global epidemic,a serious hazard to human health.Despite more comprehensive and in-depth understanding has been gained due to the long-term study of neurodegenerative diseases,its pathogenesis behind remains a mystery.It is estimated that about 98% of the transcriptional output of human genomes is RNA that does not encode protein,so called non-coding RNA（ncRNA）,which has hidden activities in life and has a broad diversity of biological functions.MicroRNA is a class of small ncRNA,which has been intensively studied;long noncoding RNA（lncRNA） has recently received much attention,with a number of accumulated research results.The role of microRNAs and lncRNAs in the pathophysiological mechanism in several neurodegenerative diseases was reviewed.

关 键 词：神经退行性疾病 MICRORNA 长非编码RNA 

分 类 号：R741[医药卫生—神经病学与精神病学] Q752[医药卫生—临床医学]