骨转移癌患者血清PⅠCP、ⅠCTP检测的意义  

Application of Determination of Serum PⅠCP and ⅠCTP Contents in Cancer Patients with Bone Metastases

作　　者：王波[1] 张军宁[1] 

机构地区：[1]苏州大学附属第一医院放疗科,江苏苏州215006

出　　处：《肿瘤防治研究》2010年第8期902-904,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨骨转移癌患者血清PⅠCP、ⅠCTP检测的临床意义。方法依据骨显像和其他影像手段将80例恶性肿瘤患者分为无骨转移组(对照组)39例和骨转移组41例,采用Soloway分级标准,将骨转移组患者再分为三个亚组:A组骨转移灶<6个20例,B组骨转移灶6～20个12例,C组骨转移灶>20个或超级显像9例。所有患者空腹抽取静脉血,采用酶联免疫检测法(ELISA)测定Ⅰ型前胶原羧基端前肽(PⅠCP)、Ⅰ型胶原羧基端肽(ⅠCTP)的数值。分析血清PⅠCP、ⅠCTP水平在各级骨转移组间的变化,判断PⅠCP、ⅠCTP与骨转移程度之间的相关性。结果 (1)骨转移癌患者血清PⅠCP、ⅠCTP水平较对照组升高,差异有统计学意义(P<0.01);(2)A、B、C三组血清PⅠCP水平依次递增,组与组之间比较差异有统计学意义(P<0.01);血清ⅠCTP水平在A、B、C三组总体有依次递增趋势,C组与A、B两组差异有统计学意义(P<0.01)。(3)血清PⅠCP水平与骨转移灶数目相关性较高,相关系数为0.5320(P<0.01);ⅠCTP水平与骨转移灶数目有一定相关性,相关系数为0.4011(P<0.05)。结论 (1)血清PⅠCP、ⅠCTP水平的检测都能反映骨转移患者的病情变化,其中血清PⅠCP水平的检测临床价值较高;(2)血清PⅠCP水平与骨转移数目的相关性较高。Objective To study the clinical value of determination of serum procollagenⅠcarboxy-terminal propeptide（PⅠCP）and carboxyterminal telopeptide of type Ⅰcollagen（ⅠCTP）contents in cancer patients with bone metastases.Methods Serum PⅠCP and ⅠCTP contents were measured with ELISA in 41 patients with bone metastases and 39 controls without bone metastases.The patients with bone metastases consisted of：（1）group A,less than 6 metastases foci,n=20（2）group B,6～20 foci,n=12（3）group C,over 20 foci,n=9.The comparison of bone turnovers among patients with different bone loads was analyzed.Results（1）Serum PⅠCP,ⅠCTP contents was significantly greater in patients with bone metastases than without bone metastases（P0.01）（2）With the increase of the extent of bone metastases,serum PⅠCP elevated,there were significant difference among each grade（P0.01）.ⅠCTP elevated,there were significant difference between Group C and Group A,B（P0.01）.（3）Levels of PⅠCP（P0.01）andⅠCTP（P0.05）were correlated with the number of foci.Conclusion（1）The determinations of serum PⅠCP andⅠCTP could reflect the clinical status of metastases size（PⅠCP more sensitive）.（2）Levels of PⅠCP correlated well to the number of foci.

关 键 词：PⅠCP ⅠCTP 骨转移 癌 

分 类 号：R730.43[医药卫生—肿瘤]