非小细胞肺癌组织中雌激素受体β和Ki-67、Bax表达的相关性  

Expression of Estrogen Receptor β in Human Non-small Cell Lung Cancer and Its Correlation with Expression of Ki-67 and Bax

作　　者：曾敏[1,2,3] 廖永德[1] 游良琨[1] 付圣灵[1] 邢昕[1] 江文洋[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院普胸外科,武汉430030 [2]华中科技大学同济医学院第二临床学院 [3]郧阳医学院附属太和医院胸心外科,湖北十堰442000

出　　处：《肿瘤防治研究》2010年第8期905-908,共4页Cancer Research on Prevention and Treatment

基　　金：教育部留学回国人员科研启动基金资助项目[(2005)55]

摘　　要：目的探讨NSCLC组织中ERβ和增殖相关蛋白Ki-67、凋亡相关蛋白Bax表达的相关性。方法采用免疫组织化学SABC法检测ERβ、Ki-67、Bax在49例NSCLC和14例良性肺病变组织中的表达,分析其表达的相关性。结果 ERβ在NSCLC中的表达率为36.7%,而在肺良性病变组织中无表达(P=0.019)。在NSCLC中,ERβ阳性组Ki-67的表达率(83.3%)显著高于ERβ阴性组(51.6%)(P=0.004),ERβ与Ki-67的表达呈正向相关;ERβ阳性组Bax的表达率(38.9%)与ERβ阴性组(51.6%)的差异无统计学意义(P=0.442),ERβ与Bax的表达无相关性。结论 ERβ在NSCLC中过表达,与Ki-67表达呈正相关,与Bax的表达无相关性,ERβ可能有促进NSCLC增殖的作用。Objective To explore the role ERβ in cell proliferation and apoptosis and investigate the expression of ERβ in NSCLC and its correlation with the expression of ki-67 and Bax.Methods The expression of ERβ,Ki-67 and Bax in 49 specimens from patients with lung cancer and 14 specimens from patients with benign lung diseases was investigated by immunohistochemistry.The correlation between ERβ and Ki-67,Bax was analyzed.Results The positive ratio of ERβ expression in NSCLC was 36.7%,whereas no clear staining was found in benign lung tissues（P=0.019）.The expression of Ki-67 in ERβ positive group was significantly higher than that in ERβ negative group of NSCLC（P=0.004）.There was no significant difference between the expression of Bax in ERβ positive group and ERβ negative group（P=0.442）.Conclusion ERβ is overexpressed in NSCLC and has a positive correlation with cell proliferation-associated protein Ki-67.ERβ may promote the proliferation of NSCLC.

关 键 词：非小细胞肺癌 ERΒ KI-67 BAX 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]