橄榄桥脑小脑萎缩的临床及影像学分析  

The clinical manifestation an MRI images of patients with olivo-ponto-cerebellar atrophy

作　　者：陈红群[1] 方旭明[1] 余晖[2] 田淑芬[1] 王毅 

机构地区：[1]贵阳医学院附属医院神经内科,贵州贵阳550004 [2]贵阳医学院附属医院影像科,贵州贵阳550004 [3]贵阳市第五人民医院

出　　处：《癫痫与神经电生理学杂志》2010年第4期226-228,共3页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的：分析橄榄桥脑小脑萎缩（OPCA）病人早期的临床表现及MRI特征，以利早期诊断。方法：对20例OPCA病人的临床表现及影像学特征进行回顾性分析。结果：OPCA病人男性多于女性，平均年龄56．5岁，其临床表现多种多样，以小脑症状、植物神经症状及锥体外系症状多见，头颅MRI以小脑和脑干萎缩为主，大脑皮质萎缩轻；其中11例病人T2WI上可见位于桥脑至延髓上部贯穿于脑干前后径的连续性细线样高信号，3例病人可见脑桥T2WI显示“十字”征。结论：成年人出现小脑性共济失调、植物神经功能紊乱和锥体外系症状，应高度怀疑OPCA，MRI有助于OPCA的诊断；“纵线”征和“十字”征在OPCA的诊断和鉴别诊断中意义重大。Objective：To analyze the clinical manifestation and the feature of MRI in the early diagnosis of olivo ponto eerebellar atrophy （OPCA）. Methods： Clinical manifestation and MRI findings in 20 patients OPCA with OPCA were retroactively analyzed. Results： The average age of patients was 56. 5 years old, with more male than femals. The clinical manifeslation varies,in which the most important ones were cerebellar ataxia ,automamie nerve deficit and extrapyramidal symptom. MRI showed obvious atrophy in cerebellum and brain stem and weak atrophY in cerebral cortex. A vertical continuous hyperinteme line signals runing from anterior to posterior of ports and medulla were seen in 11 cases. The basis pontine cross sign＇of long T2WI signals were found in 3 cases. Conclusion： The adults with cerebellar ataxia, autonamic nerve disturbance and extrapyramidal symptoms should have the possibility of OPCA. MRI may contribute to the early diagnosis. Cross sign and vertical signs are important to the diagnosis and antidiastole of OPCA.

关 键 词：橄榄桥脑小脑萎缩(OPCA) 临床表现 磁共振成像(MRI) 纵线征 十字征 

分 类 号：R742[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]