神经元特异性烯醇化酶和高敏C反应蛋白对新生儿缺氧缺血性脑病的病情及预后评价  

Neuron-specific enolase and high sensitivity C-reactive protein on neonatal hypoxic-ischemic encephalopathy＇s condition and prognosis

作　　者：陈文燕[1] 许学杰[2] 刘毅[3] 兰芙蓉[1] 

机构地区：[1]川北医学院附属第二医院儿科,四川绵阳621000 [2]川北医学院附属第二医院神经内科,四川绵阳621000 [3]川北医学院附属第二医院检验科,四川绵阳621000

出　　处：《中国医师进修杂志》2010年第24期15-17,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨血清神经元特异性烯醇化酶（NSE）和高敏C反应蛋白（hs-CRP）对新生儿缺氧缺血性脑病（HIE）患儿病情和预后的评估价值.方法 测定40例HIE患儿（HIE组）的急性期及恢复期和20例健康新生儿（对照组）血清NSE、hs-CRP水平,并分析HIE组急性期NSE、hs-CRP水平与临床分度之间的关系.结果 HIE组急性期血清NSE、hs-CRP水平[（32.88±12.61）μg/L、（6.43±2.07）mg/L]明显高于对照组[（8.62±3.58）μg/L、（2.61±0.95）mg/L]（P＜0.01）.HIE组重度患儿血清NSE、hs-CRP水平显著高于中、轻度患儿（P＜0.01）.病情越重,血清NSE、hs-CRP水平越高.结论 血清NSE、hs-CRP水平是反映脑内神经元损伤或坏死的客观指标,可作为早期判断HIE病情及预后的客观指标.Objective To investigate the serum neuron-specific enolase （NSE） and high sensitivity C-reactive protein （hs-CRP） on neonatal hypoxic-ischemic encephalopathy （HIE） in children with illness and prognosis of assessed value. Method The serum NSE, hs-CRP levels of 40 patients with HIE （HIE group） of the acute stage and convalescence, and 20 healthy neonates （control group ） were measured and the clinical sub-degree relationships were analyzed. Results The serum NSE, hs-CRP levels in HIE group of the acute stage [ （32.88 ± 12.61 ） μ g/L, （6.43 ± 2.07） mg/L] were significantly higher than those in control group [（8.62 ± 3.58） μ g/L, （2.61 ± 0.95） mg/L]（P 〈 0.01 ）. The serum NSE, hs-CRP levels in HIE group of the severe acute stage were significantly higher than those of the mild and light acute stage （P〈0.01 ）. The more severe disease, the more higher NSE, hs-CRP. Conclusion The serum NSE, hs-CRP reflect the brain neuronal damage or necrosis of the objective indicators that could be used as early objective indicators to judge the pathogenetic condition and prognosis of HIE.

关 键 词：磷酸丙酮酸水合酶 C反应蛋白质 缺氧缺血 脑 

分 类 号：R742[医药卫生—神经病学与精神病学]