酪酸梭菌活菌散预防新生儿高胆红素血症临床观察  

The observation on Clostridium butyricum powder in preventing neonatal hyperbilirubinemia

作　　者：王伟烈[1] 金玉萍[1] 程继[1] 

机构地区：[1]黑龙江大庆油田总医院儿科,黑龙江大庆163001

出　　处：《中国微生态学杂志》2010年第8期722-723,共2页Chinese Journal of Microecology

摘　　要：目的观察酪酸梭菌活菌散(商品名:宝乐安)预防新生儿高胆红素血症的临床疗效。方法将产科分娩的正常足月新生儿212例,随机分为2组,预防组106例,对照组106例,2组均在生后半小时内开始喂奶。预防组喂服酪酸梭菌活菌散500 mg/次,3次/d,用至黄疸消退,观察黄疸变化情况及不良反应。结果出生后48 h内胎便转黄率预防组为56.6%,对照组为26.4%;生后7 d内皮肤巩膜黄染达高峰预防组为58.5%,对照组为43.3%;高胆红素血症发生率预防组为7.5%,对照组为22.6%;出生后7 d内血清胆红素达高峰率预防组为62.3%,对照组为47.1%。以上各指标2组间差异均具有统计学意义(P<0.01或0.05)。结论酪酸梭菌活菌散预防新生儿高胆红素血症安全有效,值得临床推广应用。Objective To observe the efficacy of Clostridium butyricum powder（Baolean） in preventing neonatal hyperbilirubinemia.Method The breastfed newborns were randomized to 2 groups： one group（n=106） served as the control and the other,prevention group（n=106）,received Clostridium butyricum powder（0.5 g,t.i.d） with the drinking water.Result The morbidity of hyperbilirubinemia in prevention group was less than that in control group with statistical significance（P0.01）.Adverse reaction was not found.Conclusion Administration of Clostridium butyricum powder have positive effects on neonatal hyperbilirubinemia.

关 键 词：高胆红素血症 酪酸梭菌 新生儿 

分 类 号：R575[医药卫生—消化系统]