多肽修饰脂质体靶向药物递送系统研究进展  

Advances in Peptide-Modified Liposome Targeted Drug Delivery System

作　　者：吴学萍[1] 王驰[1] 

机构地区：[1]重庆医科大学药学院药物化学教研室,重庆400016

出　　处：《中国现代应用药学》2010年第8期681-685,共5页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的介绍近年来多肽修饰脂质体靶向药物递送系统的研究进展。方法查阅和归纳总结近几年相关文献。结果阐述了精氨酸-甘氨酸-天冬氨酸(RGD)多肽、丙氨酸-脯氨酸-精氨酸-脯氨酸-甘氨酸(APRPG)多肽、细胞穿透肽(CPP)、血管活性肠肽(VIP)等修饰脂质体的研究进展。多肽修饰的包载药物的脂质体可以增加药物在体内的选择性,减少药物毒副作用,提高药物治疗指数。结论多肽分子是机体内一类重要的生物活性物质,将其作为导向物以配体-受体特异性结合的方式应用于靶向药物递送系统,具有良好的研究价值和应用前景。OBJECTIVE To introduce the advances of peptide-modified liposome targeted drug delivery system.METHODS The relevant literatures in recent years were referred and summarized.RESULTS The advances of liposomes modified by arginine-glycine-aspartic（RGD） peptide,alanine-proline-arginine-proline-glycine（APRPG） peptide,cell-penetrating peptide（CPP）,vasoactive intestinal peptide（VIP） were elaborated.Peptide-modified drug-loaded liposomes may increase the selectivity of drugs in vivo and reduce side effects of drugs to improve their therapeutic index.CONCLUSION Peptide molecules are a class of important bioactive substances to the body,which are applied in targeted drug delivery system by specific-combination of ligand-receptor with good values and application prospects.

关 键 词：多肽 脂质体 靶向药物递送系统 配体 受体 

分 类 号：R945[医药卫生—微生物与生化药学]