一氧化氮合酶在卵巢肿瘤中的检测及意义  

Study on the Activity of Nitric Oxide Synthase in Ovary Tumor Tissue

作　　者：武艺[1] 王亚军[1] 于成国[1] 

机构地区：[1]中国医科大学第一临床学院妇科

出　　处：《中国医科大学学报》1999年第1期47-48,共2页Journal of China Medical University

摘　　要：目的：检测正常卵巢组织，卵巢良性肿瘤组织，卵巢恶性肿瘤组织中一氧化氮合酶（ＮＯＳ）的比活性，探讨ＮＯＳ与卵巢肿瘤间的关系。方法：ＮＯＳ活性用分光光度法检测。蛋白含量用酚试剂法检测。结果：卵巢恶性肿瘤组织中ＮＯＳ含量显著增高（Ｐ＜０．０１，卵巢良性肿瘤和正常卵巢组织中的ＮＯＳ含量无显著性差异（Ｐ＞０．０５）。卵巢恶性肿瘤组织中高、中、低分化随恶性程度升高，ＮＯＳ含量增多（Ｐ＜０．０１），与恶性程度呈正相关。结论：ＮＯ合成的增多，可能是卵巢恶性肿瘤发生及生长过程中的一个重要环节。Objective:To study the relationship between nitric oxide synthase (NOS) and ovary tumors by comparing the activity of NOS in normal ovary tissue, benign and malignant ovary tumor tissue.Methods:we used spectrophotometry method to examine the activity of NOS.Results:the activity of NOS was significantly higher in malignant ovary tumor tissue than that in normal ovary tissue and benign ovary tumor tissue(P<0 01).There was significantly positive correlationship between the activity of[KG2〗NOS and the differentiation of the[KG2〗tumor P< 0.05) [WT5”HZ〗 Conclusion:Nitric Oxide (NO) might play an important role in the oncogenesis and development of the ovarian malignant tumor. The increase of NO in malignant ovarian tumor was mainly caused by the high level of NOS.

关 键 词：卵巢肿瘤 一氧化氮 一氧化氮合酶 

分 类 号：R737.310.4[医药卫生—肿瘤]