血清MMP-2、MMP-9水平与非小细胞肺癌转移关系的研究  

Correlation of serum total MMP-2,MMP-9 levels with human non-small cell lung cancer metastasis

作　　者：雷建灵[1] 赵全年[1] 刘利[1] 高德荣[1] 

机构地区：[1]内蒙古医学院附属人民医院肿瘤科,内蒙古呼和浩特010020

出　　处：《疾病监测与控制》2010年第8期449-450,共2页Journal of Diseases Monitor and Control

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者血清MMP-2、MMP-9水平与非小细胞肺癌的关系。方法采用ELISA法检测70例非小细胞肺癌患者及26例健康志愿者血清MMP-2和MMP-9水平。结果NSCLC患者血清MMP-2和MMP-9含量显著高于正常对照组。NSCLC有转移组血清MMP-2和MMP-9水平显著高于NSCLC无转移组。结论血清MMP-2和MMP-9的水平可作为预测非小细胞肺癌转移的指标。Objectives To investigate correlation of serum total MMP-2,MMP-91evels with human non-small cell lung cancer（NSCLC）,and to evaluate the clinical value.Methods Serum total MMP-2,MMP-9 levels were detected in 70 patients with human non-small cell lung cancer and 26 healthy volunteers by ELISA.Results Mean levels of MMP-2,MMP-9 were significantly elevated in cancer samples compared with normal serum（P0.01）.A significant difference was found between levels in the presence versus the absence of metastasis（MMP-2,P0.05,MMP-9,P0.01）.MMP-2,MMP-9 levels in the sera in NSCLC metastasis group,did not,show significant correlation with sex,age,or tumor histotype（P0.05）.Conclusions Serum total MMP-2,MMP-9 levels may provide prognostic information of NSCLC metastasis.

关 键 词：非小细胞肺癌 MMP-2 MMP-9 

分 类 号：R734.2[医药卫生—肿瘤]