阿霉素治疗实验性外伤性玻璃体出血  

Adriamycin treats experimental traumatic vitreous hemorrhage in rabbits

作　　者：招志毅[1] 彭燕一[1] 

机构地区：[1]桂林医学院附属医院眼科,541001

出　　处：《江苏医药》2010年第15期1796-1798,共3页Jiangsu Medical Journal

基　　金：广西科学自然基金资助项目(桂科自0640191)

摘　　要：目的探讨玻璃体腔注射阿霉素治疗外伤性玻璃体出血的效果。方法外伤性玻璃体出血模型新西兰大白兔20只随机分为阿霉素组和生理盐水组,每组10眼。直接眼底镜观察玻璃体出血指数、增生性玻璃体视网膜病变(PVR)程度;ELISA法测定玻璃体液中细胞因子浓度。结果阿霉素组PVR程度、玻璃体腔白细胞介素-1β(IL-1β)、转化生长因子β1(TGF-β1)浓度均低于生理盐水组(P<0.05)。两组玻璃体出血指数、玻璃体腔基质金属蛋白9、血小板源性生长因子、表皮生长因子浓度无统计学差异。结论玻璃体腔注射阿霉素可以降低外伤性PVR程度,这可能与下调玻璃体腔IL-1β、TGF-β浓度有关。Objective To study the therapeutic effect of adriamycin on experimental traumatic vitreous hemorrhage in rabbits.Methods After establishment of experimental traumatic vitreous hemorrhage on the right eyes of 20 New Zealand rabbits,the rabbits were divided into adriamycin group and phosphate-buffered saline group with 10 eyes each.The bleeding index in vitreous and degree of proliferative vitreoretinopathy were estimated by direct ophthalmoscope examination.The density of cytokines in vitreous was detected by ELISA.Results The degrees of proliferative vitreoretinopathy,density of interleukin-1β and transforming growth factor-beta 1（TGF-β1） in vitreous were lower in adriamycin group than those in phosphate-buffered saline group（P〈0.05）.There were no significant differences in bleeding index of vitreous,metalloproteinase-9,pletlet-derived growth factor and epithelial growth factor between two groups（P〉0.05）.Conclusion Intravitreal injection of adriamycin may decrease the degree of proliferative vitreoretinopathy,which may be related to the suppression of IL-1β and TGF-β1 in vitreous.

关 键 词：阿霉素 外伤性玻璃体出血 细胞因子 

分 类 号：R779[医药卫生—眼科]