纳米技术在胃癌诊断和治疗中的应用  

Application of nanotechnology in the diagnosis and treatment of gastric cancer

作　　者：王国斌[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院普通外科,武汉430022

出　　处：《中华消化外科杂志》2010年第4期244-246,共3页Chinese Journal of Digestive Surgery

基　　金：国家高技术研究发展计划（863）（2007AA022001）;湖北省研究与开发计划项目（2008BCC006）;湖北省医学临床研究中心项目（JX4D07、JX4D08）

摘　　要：纳米技术研究结构尺寸为0.1～100 nm范围内的材料的组成、性质和特殊功能.在这个范围的微粒具有高反应性、高表面积、高扩散性、奇特磁性和强荧光效应等,并且其光学、电学和磁性等特性均可调控.直径＜50 nm的微粒很容易进入大部分细胞内,＜20 nm的微粒能穿过血管壁进入组织间隙.磁性纳米微粒与肿瘤特异的抗体结合可构成肿瘤特异性对比剂.Gastric cancer is the leading cause of cancer mortality. The determination of early diagnosis and treatment of gastric cancer is an important issue for medical researchers.Although there are many methods to help clinicians detect gastric cancer, the early diagnosis rate is still unsatisfactory. As a newlydeveloped field, nanomedicine provides the potential for the diagnosis and treatment of gastric cancer. Nanomaterials have functional and structural properties that are not available from either discrete or bulk materials. Nanoparticles can be modified to target cancer cells, and when carrying fluorescent agents,they can delineate the focus clearly. Nanoparticles can also kill tumor cells without injuring normal cells when they serve as the drug loader. Fluorescent nanoparticles can also guide surgeons to resect lesions completely and clear the metastatic lymph nodes completely.

关 键 词：胃肿瘤 纳米技术 诊断 治疗 

分 类 号：R735.2[医药卫生—肿瘤]