不同示踪法在胃癌前哨淋巴结检测中的应用比较  

Comparison of different tracer methods in detecting sentinel lymph nodes in gastric cancer

作　　者：程黎阳[1] 谢正勇[1] 戴观荣[1] 赵为国[1] 王弘[1] 周宏峰[1] 

机构地区：[1]广州军区广州总医院普通外科,510010

出　　处：《中华消化外科杂志》2010年第4期259-261,共3页Chinese Journal of Digestive Surgery

基　　金：广东省自然科学基金（032204）

摘　　要：目的 探讨理想的胃癌前哨淋巴结（SLN）检测方法.方法 前瞻性分析2004年1月至2008年8月广州军区广州总医院确诊的59例胃癌患者的临床资料,按随机数字表法将患者分为染料法组（20例）、核素法组（20例）和联合法组（19例）,分别或联合注射专利蓝和^99Tc^m进行SLN检测.采用t检验和Х^2检验分析SLM的检出情况及SLN判断胃癌区域淋巴结转移的准确率和假阴性率.结果 染料法组共检出SLN 38枚,平均1.9枚/例;核素法组共检出SLN 31枚,平均1.6枚/例;联合法组共检出SLN56枚,平均2.9枚/例.联合法组中同时被染料和核素标记的SLN为46枚,单独被染料和核素标记的SLN分别为6枚和4枚.3组SLN检测数目比较,差异有统计学意义（t=4.35,P〈0.05）.其中联合法组SLN的检出数目明显多于染料法组和核素法组（t=4.21,3.54,P〈0.05）.染料法组、核素法组和联合法组诊断胃癌淋巴结转移的准确率和假阴性率分别为95%（19/20）和5%（1/20）、90%（18/20）和10%（2/20）、100%（19/19）和0,其中联合法组的准确率最高（Х^2=163.01,P〈0.05）,假阴性率最低（Х^2=170.14,P〈0.05）.结论 联合染料和核素标记物示踪法是检测胃癌SLN的理想方法.Objective To explore the optimum sentinel lymph node （SLN） mapping method in gastric cancer. Methods The clinical data of 59 patients who were confirmed with gastric cancer at Guangzhou General Hospital of Guangzhou Military Command from January 2004 to August 2008 were retrospectively analysed. Patent blue V dye was used in 20 patients （group A）, technetium-99m sulfur colloid was used in 20 patients （group B）,and a combination of patent blue V dye and technetium-99m sulfur colloid were used in 19 patients （group C）.The number of SLNs detected, and accuracy and false-negative rate of SLNs in diagnosing regional lymph node metastasis were analysed by t test and chi-square test. Results The numbers of SLNs detected in groups A, B and C were 38 （1.9 per case）, 31 （1.6 per case） and 56 （2.9 per case）, respectively. In group C, 46 SLNs were screened out by patent blue V dye and technetium-99m sulfur colloid simultaneously, six SLNs were only detected by patent blue V dye and four only by technetium-99m sulfur colloid. There was a significant difference in the number of SLNs detected among the three groups （t = 4.35, P 〈 0. 05 ）. The number of SLNs detected in group C was significantly greater than that in groups A and B （t = 4. 21, 3. 54, P 〈 0.05 ）. The accuracy and false-negative rate of SLNs in diagnosing regional lymph node metastasis were 95% （19/20） and 5% （1/20） in group A, 90% （18/20） and 10% （2/20） in group B, and 100% （19/19） and 0 in group C. The accuracy was significantly higher （Х^2 = 163.01, P 〈 0.05） and the false-negative rate was significantly lower in group C compared with those in groups A and B （Х^2 = 170. 14, P 〈 0. 05）. Conclusion A combination of dye and radioactive tracer is a favorable method for detecting SLNs in gastric cancer.

关 键 词：胃肿瘤 前哨淋巴结 示踪法 染料 核素 

分 类 号：R737.9[医药卫生—肿瘤]