一例溃疡性结肠炎的循证治疗  

Evidence-based Treatment for Ulcerative Colitis:Report of one case

作　　者：袁岸龙[1] 陈志涛[2] 郭毅[2] 

机构地区：[1]湖北省孝感市中心医院消化内科,432000 [2]武汉大学医学院

出　　处：《中国全科医学》2010年第23期2595-2597,共3页Chinese General Practice

摘　　要：目的针对近期收治的1例溃疡性结肠炎缓解期患者,进行证据检索和评价,以期找到预防复发的方法。方法计算机检索CochraneLibrary(2008年第4期)、Medline(1998—2008年)、中国学术期刊全文数据库(1998—2008年)。检索主题词:ulcerative colitis;maintenance;remission;human;Meta-analysis;randomized controlled trial;systematic review。查找溃疡性结肠炎缓解期维持治疗的系统评价/Meta分析、临床随机对照试验等,并对所获证据进行评价。结果共检索出相关的随机对照试验28篇,系统评价/Meta分析8篇。通过对检索结果进行分析,为患者制定了合理的治疗方案:5-氨基水杨酸(5-ASA)1g/次,口服,3次/d;星期六、星期日各用1g5-ASA灌肠1次。经12个月的随访,该患者病情未复发,也无明显副作用发生。结论采用循证治疗的方法 ,为初治的溃疡性结肠炎缓解期患者确定合理的维持治疗方案,可有效提高治疗效果。Objective To find a method to prevent recurrence of ulcerative colitis in remission.Methods The key words such as ulcerative colitis,maintenance,remission,human,Meta-analysis,randomized controlled trial （RCT）,systematic review were retrieved from Cochrane Library （No 4,2008）,Medline （from the year 1998 to 2008）,CNKI （1998-2008）.Results A total of 28 RCTs and 8 articles of system evaluation/Meta analysis were identified.A rational treatment plan was made based on analysis of retrieved results：5-aminosalicylic acid （5-ASA）,1 g/once/daily,orally,3 times/d;5-ASA enema,1 g/once on Saturday,Sunday,respectively.After 12 months of follow-up,no recurrence was noted in the patient,nor did adverse reactions occur.Conclusion Evidence-based treatment can determine a rational maintenance therapy for initially treated ulcerative colitis patients in remission,thus to improve effectively treatment.

关 键 词：结肠炎 溃疡性 氨水杨酸 治疗 循证医学 

分 类 号：R574.621[医药卫生—消化系统]