P16^(INK4a)和Ki-67在宫颈癌前病变诊断中的意义  

Significance of expression of P16^(INK4a) and Ki-67 in the diagnosis of cervical intraepithelial neoplasia

作　　者：高琨[1] 邱明[1] 李宁[1] 陈丽艳[1] 袁之青[1] 任俊羽[1] 

机构地区：[1]云南省玉溪市人民医院病理科,653100

出　　处：《中国肿瘤临床与康复》2010年第4期321-322,326,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的研究P16INK4a、Ki-67在宫颈癌前病变中的表达及早期诊断价值。方法宫颈活检标本92例,采用免疫组织化学PV-9000二步法检测宫颈鳞癌28例,CIN 45例(CINⅢ级17例、CINⅡ级7例、CINⅠ级21例),炎性病变19例。结果在宫颈癌、CIN病变、宫颈炎P16INK4a的阳性表达率分别为100%、44.4%和10.5%,Ki-67的阳性表达率分别为100%、51.11%、21.05%,三组不同病变比较均差异有显著性(P<0.001)。P16INK4a与Ki-67表达存在正相关(r2=0.893,P<0.001)。结论 P16INk4a、Ki-67联合检测可以提高宫颈癌的早期诊断率。Objective To study the expression of P16INK4a and Ki-67 in the cervical intraepithelial neoplasia and its value in early diagnosis.Methods The expression of the P16INK4a and Ki-67 in 92 samples of cervical biopsy tissue was examined by immunohistochemistry（PV-9000 two step）.Of the 92cases,28 were cervix carcinoma,45 were cervical intraepithelial neoplasia（CIN）,19 were cervicitis.Results In cervical carcinoma,CIN and cervicitis,the positive rates for P16INK4a expression were 100%,44.4% and 10.5%.Ki-67 expression rates were 100.0%,51.1% and 21.1% respectively.There were significant differences among the three groups（P0.001）.P16INK4a was positively correlated to Ki-67（r2=0.893,P0.001）.Conclusion p16INK4a and ki-67 could be used as markers for increasing the rate of early diagnosis of the cervical cancer.

关 键 词：宫颈癌前病变 P16INK4A KI-67 诊断 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]