肿瘤转移抑制基因nm23-H_1蛋白在肺癌中的表达  

Expression of Tumor Metastasis-Suppressor Gene nm23-H 1 Protein in Lung Carcinoma

作　　者：张良 万豫尧 朱明 张尚福[1,2] 成娘 

机构地区：[1]广州中医药大学第二附属医院外科 [2]华西医科大学第一附属医院病理科

出　　处：《广州中医药大学学报》1999年第1期69-71,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：为了解ｎｍ２３－Ｈ１基因在肺癌中的表达及与肺癌淋巴转移的关系，探讨其对肺癌淋巴结转移的抑制作用，对７８例肺癌存档石蜡块进行重新切片，采用ｎｍ２３－Ｈ１单克隆抗体进行免疫组化染色（ＳＰ法）。结果：ｎｍ２３－Ｈ１蛋白表达与肺癌组织类型和淋巴结转移无关（Ｐ＞０．０５），而与肺癌细胞分化及发生有关（Ｐ＜０．０１）。结果提示ｎｍ２３－Ｈ１基因对肺癌的形成有重要作用，在肺癌中ｎｍ２３－Ｈ１基因不具有肿瘤转移抑制功能。To study the relationship between expression of gene nm23-H 1 protein and lymph node metastasis in lung carcinoma, 78 paraffin-embedded specimens of lung cancer were tested by immunohistochemical technology. The results showed that expression of gene nm23-H 1 protein was not related to histological types of lung carcinoma and lymph node metastasis (P> 0.05 ),but related to the formation of lung carcinoma and its tumor differentiation (P< 0.01 ).It is concluded that gene nm23-H 1 plays an important role in tumorigenesis and exerts no inhibitory effect on the metastasis of lung carcinoma.

关 键 词：肺肿瘤 病理学 NM23 NM23-H 转移抑制基因 

分 类 号：R734.202[医药卫生—肿瘤]