肝硬化糖代谢异常的研究  

Studies on the abnormality of glucose metabolism in cirrhosis

作　　者：张玲[1] 冼超[1] 胡少眉[2] 肖海鹏[2] 石裕明[1] 贾卫东[1] 

机构地区：[1]广州市第八人民医院,510060 [2]中山医科大学第一附属医院内分泌科

出　　处：《临床肝胆病杂志》1999年第2期103-105,共3页Journal of Clinical Hepatology

摘　　要：２６ 例肝硬化患者按口服葡萄糖耐量试验（ＯＧＴＴ） 分为糖代谢正常组和异常组，用放射免疫法测定血浆胰岛素、胰高血糖素、生长激素、皮质醇。结果：糖代谢异常组在糖负荷后０－５ ～２ｈ 血糖明显升高，空腹及糖负荷后２ ～３ｈ 血浆胰岛素显著增高，空腹及糖负荷后０－５ｈ 血浆胰高血糖素显著增高，血浆皮质醇明显降低，血浆生长激素两组比较差异无显著性，两组患者肝功能指标及胰岛素敏感性指数（ＩＳＩ） 均有明显差异。提示肝硬化糖代谢异常的发生与胰高血糖素增高、肝功能降低、组织胰岛素敏感性下降等因素有关。cases ofcirrhosis patients were dividedinto normalglucose metaboism group and dis ordered glucose metabolism group according to oralglucosetolerancetest(OGTT)-Theserum concentra tion ofinsulin,glucagon ,growth hormone and cortisone were examinted by radialim mune test-The re sultsshowed:1)The blood glucoselevel of group with disordered glucose metabolism was significantly higherthan those ofcontrols at 30min - 2h after glucoseload-2)The serum insulin level of group with disordered glucose metabolism wassignificantly higherthanthoseofcontrolsatfasting andat2h ,3hafter glucoseload-3)In disordered glucose metabolism patients the fasting and 30min after glucose load glucagonlevel wassignificantly higher,butcortisonelevel was markedly lowerthan thatin controls-No differenceinthelevelofgrowth hormon wasfound between two groups-4)There weresignificant differ enceinliverfunction data and insulin sensitivity index(ISI) between two groups-These data suggested that the abnormality of glucose metabolism in cirrhosis are related to the elevated glucagon,poor liver function and declined sensitivity oftissue toinsulin-

关 键 词：肝硬化 糖耐量 血浆胰岛素 生长激素 皮质醇 

分 类 号：R575.202[医药卫生—消化系统]