硫普罗宁治疗急性胰腺炎肝损害临床疗效及机制探讨  

Clinical effect and pathogenesis of tiopronin in treating acute pancreafitis complicated with fiver damages

作　　者：栾春艳[1] 刘志刚[2] 周洪美[1] 张银华[1] 赵存新[1] 

机构地区：[1]潍坊医学院青州临床学院消化内科,262500 [2]潍坊医学院青州临床学院心内科,262500

出　　处：《中国医师进修杂志》2010年第25期6-8,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨硫普罗宁治疗急性胰腺炎合并肝损害的临床疗效及机制.方法 将81例急性胰腺炎肝损害患者按入院顺序随机分成两组,对照组40例给予常规治疗,治疗组41例在对照组治疗的基础上加用硫普罗宁.两组患者于治疗第1、8天分别检测肝功能、胰脂肪酶和C反应蛋白（CRP）,同时观察住院时间.结果 治疗第8天两组肝功能均有好转,胰脂肪酶、CRP均下降,但治疗组较对照组各项指标好转更明显（P〈0.05）;治疗组轻症急性胰腺炎患者的住院时间较对照组轻症急性胰腺炎患者明显缩短[（8.6±2.7）d比（13.8±3.5）d]（P〈0.05）.结论 硫普罗宁对急性胰腺炎并发肝损害有很好疗效,并且对急性胰腺炎本身亦有治疗作用,其机制可能与其抑制炎性介质和清除氧自由基等作用有关.Objective To investigate the clinical effect and pathogenesis of tiopronin in treating acute pancreatitis complicated with liver damages. Methods Eighty-one patients with acute pancreatitis complicated with liver damages were randomly divided into two groups. The control group （40 cases） received routine treatment, and the treatment group （41 cases ） received routine treatment and tiopronin. The liver function, pancreatic enzyme indexes and C-reactive protein （CRP）, the length of hospital stay was recorded. Results After 8 days＇ treatment, the liver function improved, and the levels of pancreatic enzyme indexes and CRP were decreased significanfly in both groups, and these changes were more obvious in treatment group （P 〈0.05）. The length of hospital stay of mild acute pancreatitis in treatment group was significantly shorter than that in control group [ （8.6 ± 2.7 ） d vs. （ 13.8 ± 3.5 ） d ] （P 〈 0.05 ）. Conclusions Tiopronin has beneficial effects in treating acute pancreatitis complicated with liver damages,and it has a therapeutic effect in acute pancreatitis at the same time. The mechanism may be related with the inhibition of inflammatory mediators, oxygen free radicals scavenging and other effects.

关 键 词：硫普罗宁 胰腺炎 肝功能衰竭 

分 类 号：R57[医药卫生—消化系统]