多层螺旋CT灌注成像对肝癌经导管肝动脉栓塞化疗前后血供变化的应用价值  被引量:1

The value of multi-slice spiral CT perfusion imaging in evaluating the changes of blood supply of hepatocellular carcinoma before and after transcatheter hepatic arterial

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作  者:周霖[1] 邹文远[1] 陈玉峰[1] 

机构地区:[1]郧阳医学院附属人民医院放射科,湖北十堰442200

出  处:《中国医师进修杂志》2010年第25期18-20,共3页Chinese Journal of Postgraduates of Medicine

摘  要:目的 研究多层螺旋CT灌注成像在评价肝癌经导管肝动脉栓塞化疗(TACE)前后血流动力学改变中的价值.方法 17例肝癌患者TACE术前及术后行CT灌注扫描.计算肝血流量(HBF)、肝血容量(HBV)、平均通过时间(MTT)、毛细血管表面通透性(PS)、肝动脉灌注分数(HAF),并计算肝动脉灌注量(HAP)、门静脉灌注量(PVP).根据各灌注参数值评价肝癌TACE前后血流动力学改变.结果 TACE术后,HBF、HBV和HAP[(167.89±96.06)ml/(100 g·min),(14.95±15.13)ml/100 g,(97.71±68.18)ml/(100g·min)]较TACE术前[(250.59±129.56)ml/(100 g·min),(24.44±20.03)ml/100 g,(184.61±178.83)ml/(100 g·min)]减少(P〈0.05或〈0.01),而MTT和PS在TACE术前、术后比较差异无统计学意义(P〉0.05).结论 肝脏灌注参数可有效评价TACE前后肝癌组织的血流灌注改变,具有重要的临床应用价值.Objective To study the multi-slice spiral CT (MSCT) perfusion imaging in evaluating the changes of blood supply of hepatocellular carcinoma( HCC ) before and after transcatheter hepatic arterial chemoembolization (TACE). Methods Before and after TACE, MSCT perfusion was performed in 17 patients with HCC. The perfusion indexes such as hepatic blood flow (HBF), hepatic blood volume(HBV),mean transit time (MTT),hepatic arterial fracture (HAF),permeability surface (PS), hepatic artery perfusion (HAP), portal venous perfusion (PVP) were calculated. The hemodynamic changes of HCC after TACE were evaluated according to perfusion parameters. Results After TACE, HBF,HBV and HAP found in MTT and PS before and after TACE (P 〉 0.05). Conclusion The parameters of MSCT perfusion imaging( HBF, HBV and HAP) can effectively evaluate the hemodynamic changes of HCC after TACE, and has important value in chnical application.

关 键 词:肝肿瘤 诊断显像 体层摄影术 X线计算机 

分 类 号:R735.7[医药卫生—肿瘤]

 

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