大鼠正畸牙移动初期P2X_3受体在牙髓及牙周膜中的表达变化  

Expression of P2X_3 receptors in rat dental pulp and periodental tissue at early stage during experimental tooth movement

作　　者：卢云[1,2] 贵林[1] 常新[1] 王晟[2] 赖文莉[2] 

机构地区：[1]大连医科大学口腔医学院口腔正畸教研室,辽宁大连116044 [2]四川大学华西口腔医院正畸科,四川成都610041

出　　处：《大连医科大学学报》2010年第4期383-387,共5页Journal of Dalian Medical University

基　　金：国家自然科学基金资助项目(No.30471912)

摘　　要：[目的]研究正常大鼠牙髓牙周膜P2X3受体的表达及正畸牙移动初期的变化。[方法]利用免疫组织化学方法检测大鼠第1磨牙牙髓及牙周组织P2X3受体的表达及分布。[结果]P2X3受体表达牙髓多于牙周膜,在牙髓主要分布于成牙本质细胞层,并伸向前期牙本质和牙本质;在牙周膜以牙根中部和根尖部居多,远离牙骨质;在正畸牙移动初期牙髓、牙周膜的表达均增强。[结论]P2X3在牙髓牙周膜均有表达,在正畸牙移动初期表达增强,可能在正畸初期疼痛信息的传递中起着一定作用。[Objective] To study the expression of P2X3 receptors in rat dental pulp and periodental ligament,and the expression change at early stage during experimental tooth movement.[Methods] Immunohistochemistry was used to observe the expression anddistribution of P2X3 receptors in rat dental pulp and periodental ligament.[Results] In pulp P2X3 receptors were mainly distributed in the odontoblast cell layer and were extending toward dentin layer;and in periodental membrane P2X3 receptors were mainly distributed in the central and apical root area,keeping away from the cementum.The expression of P2X3 receptors in dental pulp was stronger than that in periodontal ligament,which increased at early stage during experimental tooth movement.[Conclusion] P2X3 receptors express in rat dental pulp and periodontal ligament,and express highly at early stage during experimental tooth movement,which may play a role during early pain information transmission.

关 键 词：P2X3受体 牙髓 牙周膜 疼痛 ATP 

分 类 号：R783.5[医药卫生—口腔医学]