神经-内分泌-免疫网络与炎症性肠病  

Neuro-endocrine-immune network and inflammatory bowel disease

作　　者：袁川评[1] 王玮[1] 柳巨雄[1] 

机构地区：[1]吉林大学畜牧兽医学院,吉林省长春市130062

出　　处：《世界华人消化杂志》2010年第19期2024-2028,共5页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30671535;30871840~~

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是一种病因不明的慢性胃肠道炎症性疾病,他主要包括克罗恩病(Crohn's disease,CD)和溃疡性结肠炎(ulcerative colitis,UC).近年来,大量研究表明,其发病机制与神经-内分泌-免疫网络(neuro-endocrine-immunenetwork)密切相关.因此本文分别从下丘脑-自主神经系统轴(hypothalamus-autonomic nervous systemaxis,HANS)、下丘脑-垂体-肾上腺轴(hypothalamic-pituitary-adrenal axis,HPA)和免疫三个方面阐述该网络在IBD发生发展过程中的重要作用.Inflammatory bowel disease （IBD） is a group of chronic inflammatory gastrointestinal diseases of unknown etiology,including mainly ulcerative colitis （UC） and Crohn＇s disease （CD）.Numerous studies have indicated that there is considerable relationship between the pathogenesis of IBD and the neuro-endocrine-immune network.This article will describe the essential role of the neuro-immune-endocrine network in the development of IBD in terms of the hypothalamus-autonomic nervous system （HANS） axis,hypothalamic-pituitary-adrenal （HPA） axis and immunity.

关 键 词：炎症性肠病 神经-内分泌-免疫网络 下丘脑-自主神经系统轴 下丘脑-垂体-肾上腺轴 免疫 

分 类 号：R574[医药卫生—消化系统]